Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin
Abstract
Recent data indicate an important contribution of coagulation factor (F)XII to in vivo thrombus formation. Because fibrin structure plays a key role in clot stability and thrombosis, we hypothesized that FXII(a) interacts with fibrin(ogen) and thereby regulates clot structure and function. In plasma and purified system, we observed a dose-dependent increase in fibrin fiber density and decrease in turbidity, reflecting a denser structure, and a...
Paper Details
Title
Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin
Published Date
Oct 6, 2011
Journal
Volume
118
Issue
14
Pages
3942 - 3951
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