Robert A. S. Ariëns
University of Leeds
FibrinolysisFibrinogenFactor XIIIFibrinMedicine
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Publications 158
#1Fraser L. Macrae (University of Leeds)H-Index: 7
#2Barnaby Peacock-Young (University of Leeds)H-Index: 1
Last. Daniel Payne (Leeds Teaching Hospitals NHS Trust)
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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement-mediated intravascular hemolysis and thrombosis. The increased incidence of PNH-driven thrombosis is still poorly understood, but unlike other thrombotic disorders, is thought to largely occur through complement-mediated mechanisms. Treatment with a C5 inhibitor, eculizumab, has been shown to significantly reduce the number of thromboembolic events in these patients. Based on previously descri...
#1Chavalit Supsrisunjai (Guy's Hospital)H-Index: 1
#2Chao Kai Hsu (NCKU: National Cheng Kung University)H-Index: 17
Last. John Muzic (Guy's Hospital)H-Index: 66
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Abstract Dermatofibromas are common benign skin lesions, the etiology of which is poorly understood. We identified two unrelated pedigrees in which there was autosomal dominant transmission of multiple dermatofibromas. Whole exome sequencing revealed a rare shared heterozygous missense variant in F13A1 gene encoding factor XIII subunit A, a transglutaminase involved in hemostasis, wound healing, tumor growth, and apoptosis. The variant (p.Lys679Met) has an allele frequency of 0.0002 and is predi...
1 CitationsSource
#1Shiraazkhan Abdul (Erasmus University Medical Center)H-Index: 3
#2Dick H. W. Dekkers (Erasmus University Medical Center)H-Index: 25
Last. Shirley Uitte de Willige (Erasmus University Medical Center)H-Index: 4
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Background: Alpha-2-antiplasmin (α2AP) is the main natural inhibitor of plasmin. The C-terminus of α2AP is crucial for the initial interaction with plasmin(ogen) and the rapid inhibitory mechanism. Approximately 35% of circulating α2AP has lost its C-terminus (non-plasminogen binding α2AP/NPB-α2AP) and thereby its rapid inhibitory capacity. The C-terminal cleavage site of α2AP is still unknown. A commercially available monoclonal antibody against α2AP (TC 3AP) detects intact but not NPB-α2AP, su...
#1Boris A. Anokhin (University of Louisville)H-Index: 2
#2William L. Dean (University of Louisville)H-Index: 31
Last. Muriel C. Maurer (University of Louisville)H-Index: 12
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: Factor XIIIA (FXIIIA) is a transglutaminase that cross-links intra- and extracellular protein substrates. FXIIIA is expressed as an inactive zymogen, and during blood coagulation, it is activated by removal of an activation peptide by the protease thrombin. No such proteolytic FXIIIA activation is known to occur in other tissues or the intracellular form of FXIIIA. For those locations, FXIIIA is assumed instead to undergo activation by Ca2+ ions. Previously, we demonstrated a monomeric state f...
2 CitationsSource
#1Rui-Gang Xu (University of Leeds)H-Index: 1
#2Robert A. S. Ariëns (University of Leeds)H-Index: 43
The structure of blood clots has recently become a hot topic in the scientific and medical literature. A search on PubMed for ‘clot structure’ results in >1,000 publications in the last 25 years, with >400 in the last five years alone. The reason for this surge in studies of the structure of
#1Cédric Duval (University of Leeds)H-Index: 11
#2Aldo ProfumoH-Index: 13
Last. Mattia RoccoH-Index: 23
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BACKGROUND: Fibrin polymerization, following fibrinopeptides A and B (FpA, FpB) cleavage, relies on newly exposed alpha- and beta-chains N-termini (GPR, GHR; A-, B-knobs, respectively) engaging preexistent a and b pockets in other fibrin(ogen) molecules' gamma- and (B)beta-chains C-terminal regions. A role for mostly disordered (A)alpha-chains C-terminal regions "bridging" between fibrin molecules/fibrils has been proposed. OBJECTIVES: Fibrinogen Detroit is a clinically observed mutation (Aalpha...
#1Noppadol Kietsiriroje (University of Leeds)
#1Noppadol Kietsiriroje (University of Leeds)H-Index: 2
Last. Ramzi Ajjan (University of Leeds)H-Index: 37
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: The term double diabetes (DD) has been used to refer to individuals with type 1 diabetes (T1D) who are overweight, have a family history of type 2 diabetes and/or clinical features of insulin resistance. Several pieces of evidence indicate that individuals who display features of DD are at higher risk of developing future diabetes complications, independently of average glucose control, measured as glycated haemoglobin (HbA1c) concentration. Given the increased prevalence of individuals with f...
#1Alexandre Slater (University of Birmingham)H-Index: 3
#2Gina Perrella (UM: Maastricht University)H-Index: 2
Last. Steve P. Watson (University of Birmingham)H-Index: 76
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AbstractGPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain. Recently, fibrin and fibrinogen have been identified as ligands for GPVI and shown to induce signalling in support of thrombus formation and stabilization. Contrasting observations have been reported on whether fibrin binds to monomeric or dimeric GPVI, or to neither form. In this article, we discuss reason...
4 CitationsSource
#1Stephen R. Baker (University of Leeds)H-Index: 2
#2Michal Zabczyk (Jagiellonian University Medical College)H-Index: 6
Last. Robert A. S. Ariëns (University of Leeds)H-Index: 43
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BACKGROUND:Venous thromboembolism (VTE) is associated with a high risk of recurrent events after withdrawal of anticoagulation. OBJECTIVES:The aim of this study was to determine the difference in plasma clot mechanical properties from patients having recurrent (r) versus non-recurrent (nr) VTE. METHODS:We previously developed a system for determining clot mechanical properties using an in-house magnetic tweezers system. This system was used to determine the mechanical properties of clots made fr...