M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury
Abstract
The role of muscarinic receptor subtypes in modulating acute liver injury is unknown. We detected M1 muscarinic receptor (M1R) expression in human and murine hepatocytes, and investigated the consequences of M1R deficiency on acute liver injury in vivo and inhibiting M1R activation on hepatocyte injury in vitro. Age-matched wild-type (WT) and M1R-deficient (Chrm1(-/-)) male mice were injected intraperitoneally with 200mg/kg acetaminophen (APAP)...
Paper Details
Title
M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury
Published Date
Jan 1, 2015
Volume
78
Pages
66 - 81
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