Free Radical Biology and Medicine
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#1Toshiaki Teratani (Keio: Keio University)H-Index: 12
#2Kengo Tomita (National Defense Medical College)H-Index: 22
Last. Takahiko Shimizu (Chiba University)H-Index: 30
view all 17 authors...
Abstract The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ has been implicated in the pathogenesis of various human diseases including fatty liver. Although nuclear translocation of PPARγ plays an important role in PPARγ signaling, details of the translocation mechanisms have not been elucidated. Here we demonstrate that PPARγ2 translocates to the nucleus and activates signal transduction through H2O2-dependent formation of a PPARγ2 and transportin (Tnpo)1 complex via redox...
#1Jin-Young Lee (MCW: Medical College of Wisconsin)H-Index: 1
#2Whasun Lim (Kookmin University)H-Index: 4
Last. Gwonhwa Song (KU: Korea University)H-Index: 29
view all 3 authors...
Abstract Phytoestrogens are naturally derived estrogen-like therapeutic compounds that have long been studied for their role as anti-cancer agents and supplements during chemotherapy. Bavachin is a therapeutic phytoestrogen used to treat cancer, inflammation, and diabetes mellitus. Though the therapeutic effects of bavachin on various diseases have been explored, its anti-cancer effects and related mechanisms in human placental choriocarcinoma remain unknown. This is the first study to identify ...
Abstract Loss of follicles together with decreased oocyte quality and quantity contribute to age-associated ovarian senescence and infertility. Although underlying mechanisms for ovarian senescence are still unknown, mitochondrial dysfunctions have been reported. Here, we showed age-dependent decreases in ovarian Nicotinamide Adenine Dinucleotide (NAD+) levels in mice whereas supplementing aging mice with nicotinamide riboside (NR), an NAD+ precursor, increased ovarian NAD+ content. We found tha...
#1Chia-Yu Chang (STUST: Southern Taiwan University of Science and Technology)H-Index: 1
#2Jen-Yin Chen (CNU: Chia Nan University of Pharmacy and Science)
Last. Miao-Lin Hu (NCHU: National Chung Hsing University)H-Index: 4
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Abstract Stroke is a major public health problem and ranks third most common cause of death in adults worldwide. Thrombolysis with recombinant tissue plasminogen activator and endovascular thrombectomy are the main revascularization therapies for acute ischemic stroke. However, ischemia-reperfusion injury, mainly caused by oxidative/nitrosative stress injury, after revascularization therapy can result in worsening outcomes. For better clinical prognosis, more and more studies have focused on the...
#1Z. Kaufman (UC Davis: University of California, Davis)
#2Gabriela A. Salvador (UNS: Universidad Nacional del Sur)H-Index: 18
Last. Patricia I. Oteiza (UC Davis: University of California, Davis)H-Index: 48
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Abstract Zinc plays a key role in the modulation of neuronal redox homeostasis. A decreased zinc availability is associated with neuronal NADPH oxidase and nitric oxide synthase activation, deregulation of redox signaling, and impaired glutathione synthesis. The present work tested the hypothesis that zinc is necessary in the neuronal defense response against dopamine (DA)-induced oxidative stress, in particular through heme oxygenase-1 (HO-1) upregulation. DA showed higher cytotoxicity when zin...
#1Anna Jørs (UCPH: University of Copenhagen)
#2Morten Asp Vonsild Lund (UCPH: University of Copenhagen)H-Index: 3
Last. Jens-Christian Holm (UCPH: University of Copenhagen)H-Index: 23
view all 6 authors...
Abstract Purpose Oxidative stress may play an important role in childhood obesity and increased cardiometabolic risk. 8-oxo-7,8-dihydroguanosine (8-oxoGuo) from oxidation of RNA and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) from oxidation of DNA are excreted into urine and function as biomarkers for oxidative stress reflecting the modification rate of nucleic acids by oxidation. This study investigates the associations between urinary markers of nucleic acid oxidation and Body Mass Index (BM...
#1Luke Carroll (UCPH: University of Copenhagen)H-Index: 3
#2Kelly A Gardiner (UCPH: University of Copenhagen)H-Index: 1
Last. Michael J. Davies (UCPH: University of Copenhagen)H-Index: 94
view all 10 authors...
Abstract Selenium compounds have been identified as potential oxidant scavengers for biological applications due to the nucleophilicity of Se, and the ease of oxidation of the selenium centre. Previous studies have reported apparent second order rate constants for a limited number of oxidants (e.g. HOCl, ONOOH) with some selenium species, but these data are limited. Here we provide apparent second order rate constants for reaction of selenols (RSeH), selenides (RSeR′) and diselenides (RSeSeR’) w...
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#1Lucía Fernández-del-Río (UCLA: University of California, Los Angeles)H-Index: 2
#2Miranda E. Kelly (UCLA: University of California, Los Angeles)
Last. Catherine F. Clarke (UCLA: University of California, Los Angeles)H-Index: 47
view all 8 authors...
Abstract Coenzyme Q (CoQ) is an essential player in the respiratory electron transport chain and is the only lipid-soluble antioxidant synthesized endogenously in mammalian and yeast cells. In humans, genetic mutations, pathologies, certain medical treatments, and aging, result in CoQ deficiencies, which are linked to mitochondrial, cardiovascular, and neurodegenerative diseases. The only strategy available for these patients is CoQ supplementation. CoQ supplements benefit a small subset of pati...
#1John P. Gotham (UAB: University of Alabama at Birmingham)H-Index: 1
#2Rui Li (UAB: University of Alabama at Birmingham)H-Index: 3
Last. Qian Li (UAB: University of Alabama at Birmingham)H-Index: 13
view all 6 authors...
Abstract Electron Paramagnetic Resonance (EPR) spectroscopy coupled with spin traps/probes enables quantitative determination of reactive nitrogen and oxygen species (RNOS). Even with numerous studies using spin probes, the methodology has not been rigorously investigated. The autoxidation of spin probes has been commonly overlooked. Using the spin probe 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine hydrochloride (CMH), the present study has tested the effects of metal chelators, te...
#1Jin-Young Lee (MCW: Medical College of Wisconsin)H-Index: 1
#2Jiyeon Ham (KU: Korea University)H-Index: 3
Last. Gwonhwa Song (KU: Korea University)H-Index: 29
view all 4 authors...
Abstract Apomorphine, a therapeutic agent for neurological diseases, is structurally similar to dopamine, and thereby holds potential in cancer therapy. However, there are no reports regarding its anti-cancer effects on human epithelial ovarian cancers (EOCs); therefore, we aimed to elucidate the mechanism underlying its action after drug repositioning. Apomorphine inhibited the proliferation of ES2 and OV90 EOC cells by inducing caspase activation and mitochondrion-associated apoptosis; it also...
Top fields of study
Oxidative stress
Reactive oxygen species
Diabetes mellitus