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Free Radical Biology and Medicine
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#1Brandon Griess (UNMC: University of Nebraska Medical Center)H-Index: 1
#2Shakeel U. R. Mir (UNMC: University of Nebraska Medical Center)H-Index: 3
Last.Melissa Lt Teoh-Fitzgerald (UNMC: University of Nebraska Medical Center)H-Index: 4
view all 4 authors...
Abstract Tumor associated macrophages (TAM) enhance the aggressiveness of breast cancer via promoting cancer cell growth, metastasis, and suppression of the patient's immune system. These TAMs are polarized in breast cancer with features more closely resembling the pro-tumorigenic and immunosuppressive M2 type rather than the anti-tumor and pro-inflammatory M1 type. The goal of our study was to examine primary human monocyte-derived M1 and M2 macrophages for key redox differences and determine s...
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#1Junjie LiuH-Index: 3
#2Kazumi IwataH-Index: 18
Last.Chihiro Yabe-NishimuraH-Index: 33
view all 12 authors...
Abstract The involvement of reactive oxygen species (ROS) has been suggested in the development of inflammatory bowel disease (IBD). An impaired intestinal barrier function is common in IBD patients. Here, we report the central role of NOX1/NADPH oxidase, a major source of ROS in nonphagocytic cells, in intestinal barrier dysfunction. By in vivo imaging using L-012 as a probe, a time-dependent increase in ROS was demonstrated in the abdomen of wild-type mice (WT) administered lipopolysaccharide ...
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#1Vu Thao-Vi Dao (UM: Maastricht University)H-Index: 3
#2Mahmoud H. Elbatreek (UM: Maastricht University)H-Index: 1
Last.Harald H.H.W. Schmidt (UM: Maastricht University)H-Index: 73
view all 8 authors...
Abstract Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however, has failed in multiple clinical trials to provide patient benefit. Instead, pharmacological modulation of disease-relevant, enzymatic sources of ROS appears to be an alternative, more promising and meanwhile successfully validated approach. With respect to targets, the family of NADPH oxidases (NOX) stands out as m...
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#1Michael O. Isei (UPEI: University of Prince Edward Island)
#2Collins Kamunde (UPEI: University of Prince Edward Island)H-Index: 19
Abstract High energy demand for continuous mechanical work and large number of mitochondria predispose the heart to excessive reactive oxygen species (ROS) production that may precipitate oxidative stress and heart failure. While mitochondria have been proposed as a unifying cellular target and driver of adverse effects induced by diverse stressful states, there is limited understanding of how heart mitochondrial ROS homeostasis is affected by combinations of stress factors. Thus, we probed the ...
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#1Jelena Korać Jačić (Life Sciences Institute)
#2Ljiljana Nikolić (University of Belgrade)H-Index: 6
Last.Jelena Bogdanović Pristov (Life Sciences Institute)H-Index: 8
view all 9 authors...
Abstract Upon release in response to stress, epinephrine (Epi) may interact with labile iron pool in human plasma with potentially important (patho)physiological consequences. We have shown that Epi and Fe3+ build stable 1:1 high-spin bidentate complex at physiological pH, and that Epi does not undergo degradation in the presence of iron. However, the interactions of Epi with the more soluble Fe2+, and the impact of iron on biological activity of Epi are still not known. Herein we showed that Ep...
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#1Quach Ngoc Tung (FU: Free University of Berlin)H-Index: 2
#2Tobias Busche (FU: Free University of Berlin)H-Index: 10
Last.Haike Antelmann (FU: Free University of Berlin)H-Index: 45
view all 5 authors...
Abstract MarR-family transcription factors often control antioxidant enzymes, multidrug efflux pumps or virulence factors in bacterial pathogens and confer resistance towards oxidative stress and antibiotics. In this study, we have characterized the function and redox-regulatory mechanism of the MarR-type regulator HypS in Mycobacterium smegmatis. RNA-seq transcriptomics and qRT-PCR analyses of the hypS mutant revealed that hypS is autoregulated and represses transcription of the co-transcribed ...
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#1Guanghui Deng (Southern Medical University)H-Index: 2
#2Yunjia Li (Southern Medical University)
Last.Lei Gao (Southern Medical University)H-Index: 4
view all 15 authors...
Abstract Ferroptosis is a new regulated cells death manner defined as results of iron-dependent accumulation of lipid peroxidation. However, the specific mechanisms of regulating ferroptosis remain unclear. In our present study, we demonstrated that Caveolin-1 (Cav-1) played a central role in protecting hepatocytes against ferroptosis in autoimmunity-mediated hepatitis (AIH). The downregulated Cav-1 in liver tissues, accompanied by ferroptotic events and RNS production, were contributed to the o...
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#1Shuting Cao (ZJU: Zhejiang University)H-Index: 5
#2Chunchun Wang (ZJU: Zhejiang University)H-Index: 4
Last.Caihong Hu (ZJU: Zhejiang University)H-Index: 22
view all 6 authors...
Abstract The gut epithelial is known as the most critical barrier for protection against harmful antigens and pathogens. Oxidative stress has been implicated in the dysfunction of the intestine barrier. Hence, effective and safe therapeutic approaches for maintaining intestinal redox balance are urgently needed. Curcumin has gained attention for its vast beneficial biological function via antioxidative stress. However, whether the curcumin can relief intestine damage and mitochondrial injury ind...
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#1Kaushiki M. Kadam (National Institute for Research in Reproductive Health)H-Index: 5
#2Vrinda V. Khole (National Institute for Research in Reproductive Health)H-Index: 12
Last.Bini Ramachandran (Thermo Fisher Scientific)
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Abstract The sperm tail outer dense fibres (ODFs) contribute passive structural role in sperm motility. The level of disulphide cross-linking of ODFs and their structural thickness determines flagellar bending curvature and motility. During epididymal maturation, proteins are internalized to modify ODF disulphide cross-linking and enable motility. Sperm thiol status is further altered during capacitation in female tract. This suggests that components in female reproductive tract acting on thiol/...
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#1Gang Cheng (MCW: Medical College of Wisconsin)H-Index: 13
#2Jing Pan (MCW: Medical College of Wisconsin)H-Index: 15
Last.Balaraman KalyanaramanH-Index: 90
view all 11 authors...
Abstract Previous studies have shown that reactive oxygen species (ROS) such as superoxide or hydrogen peroxide generated at low levels can exert a tumor-promoting role via a redox-signaling mechanism. Reports also suggest that both tumorigenesis and tumor growth are associated with enhanced ROS formation. However, whether ROS levels or ROS-derived oxidative marker levels increase during tumor growth remains unknown. In this study, in vivo bioluminescence imaging with a boronate-based pro-lucife...
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Top fields of study
Chemistry
Oxidative stress
Antioxidant
Reactive oxygen species
Biochemistry
Diabetes mellitus