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Free Radical Biology and Medicine
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#1Henrik E. Poulsen (Copenhagen University Hospital)H-Index: 53
#2Allan Weimann (Copenhagen University Hospital)H-Index: 25
Last.Mogens Fenger (Copenhagen University Hospital)H-Index: 32
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Abstract Background The oxidized guanine nucleosides, 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), derived from DNA and RNA, respectively, were used to investigate the importance of oxidative stress to nucleic acids in vivo. High urinary excretion of 8-oxodG is associated with cancer development, whereas high urinary excretion of 8-oxoGuo is associated with mortality in type 2 diabetes. Like creatinine, these small water-soluble molecules are not reabs...
#1Simiao Qiao (CPU: China Pharmaceutical University)H-Index: 4
#2Rui Liu (CPU: China Pharmaceutical University)H-Index: 1
Last.Yue Dai (CPU: China Pharmaceutical University)H-Index: 20
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Abstract Bergenin, a plant polyphenol, has been reported to lower the blood glucose level and ameliorate kidney function in streptozotocin (STZ)-induced diabetic rats. Herein, its protective effect on diabetic nephropathy (DN) was explored in view of extracellular matrix (ECM) generation in glomerular mesangial cells. Glomerular mesangial cells were treated with high glucose, and Q-PCR as well as Western blot were used to determine the expression of ECM. To establish the participation and role o...
#1Éder Ricardo Petry (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 1
#2Diego de Freitas Dresch (UFRGS: Universidade Federal do Rio Grande do Sul)
Last.Clovis Milton Duval Wannmacher (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 34
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Abstract Skeletal muscle disuse results in myofibrillar atrophy and protein degradation, via inflammatory and oxidative stress-mediated NF-kB signaling pathway activation. l -glutamine supplementation has antioxidant properties and modulates cytoprotective 70-kDa heat shock protein (HSP70) expression. This study investigated the effects of oral supplementation with l -glutamine plus l -alanine (GLN + ALA), both in the free forms and L-alanyl- l -glutamine (DIP), on glutamine-glutathione (GSH) ax...
#1Xiao-Xue Li (SEU: Southeast University)H-Index: 8
#2Sunkai Ling (SEU: Southeast University)H-Index: 2
Last.Peilin Huang (SEU: Southeast University)H-Index: 2
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Abstract The cardiovascular efficacy of glucose-lowering drugs is needed due to the cardiovascular complication in type 2 diabetes mellitus (T2DM). Acarbose is an α-glucosidase inhibitor that suppresses postprandial hyperglycemia, however, the cardiovascular protection of acarbose has still remained controversial. NLRP3 inflammasome activation mediated tight junction disruption, a hallmark event of endothelial barrier dysfunction leading to endothelial hyperpermeability in diabetes. Given the an...
#1Lulu Ren (Capital Medical University)H-Index: 1
#2Fei-fei Han (Capital Medical University)H-Index: 6
Last.Lihong Liu (Capital Medical University)H-Index: 7
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Abstract Clusterin (CLU) is a stress-responding protein associated with cytoprotection in a broad range of pathological processes. However, clusterin's function in diabetes-induced endothelial dysfunction has not been defined. Herein, using two diabetes models, we investigated the role of clusterin in endothelial dysfunction triggered by diabetes and the molecular mechanisms involved. The results revealed that clusterin overexpression inhibited ICAM-1/VCAM-1 expression in aortas and improved end...
Abstract The adverse effects of ionizing radiation (IR) on biological tissues are mediated via increased production of reactive oxygen species (ROS) often resulting in life-threatening injuries. The effects of ionizing radiation on cells include the formation of ROS, DNA single-strand breaks, double-strand breaks, and extensive base modifications inducing the complex DNA damage. The capacity to endure the radiation insult lies in the biochemical mechanisms and structural properties in many bacte...
#1Irantzu Pérez-Ruiz (UPV/EHU: University of the Basque Country)
#2Susana Meijide (UPV/EHU: University of the Basque Country)H-Index: 1
Last.José Ignacio Ruiz-Sanz (UPV/EHU: University of the Basque Country)H-Index: 11
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Abstract Controlled ovarian hyperstimulation cycle with exogenous gonadotropins (COH) is associated with clinical complications. The aim of this work was to determine whether COH alters the physiological antioxidant status of follicular fluid in women with no reproductive dysfunction, compared to the natural cycle (NC). In this longitudinal study, forty-one women (oocyte donors) consecutively underwent NC and COH. Follicular fluid was collected at oocyte retrieval and different redox biomarkers ...
#1Greg A. Knock ('KCL': King's College London)H-Index: 11
Abstract The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase (NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium, NOX generates reactive oxygen species (ROS) that act as second messengers, contributing to the control of normal vascular function. NOX activity is altered in response to a variety of stimuli, including G-protein coupled receptor agonists, growth-factors, perfusion pressure, flow and hypoxia. NOX-derived ROS are inv...
#1Hereward J. Wimborne (MUSC: Medical University of South Carolina)
#2Kenji Takemoto (MUSC: Medical University of South Carolina)H-Index: 6
Last.Zhi Zhong (MUSC: Medical University of South Carolina)H-Index: 32
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Abstract Background and aim Liver fibrosis is a leading cause of mortality worldwide. Oxidative stress is a key component in the pathogenesis of liver fibrosis. We investigated the role of aldehyde formation resulting from lipid peroxidation in cholestatic liver injury and fibrosis. Methods C57Bl/6J mice underwent bile duct ligation (BDL) or sham operation. One hour after surgery and daily thereafter, animals were given Alda-1 (20 mg/kg, s.c.), an aldehyde dehydrogenase-2 activator, or equivalen...
#1Run-Qing Xue (Xi'an Jiaotong University)H-Index: 3
#2Ming Zhao (Xi'an Jiaotong University)H-Index: 10
Last.Wei-JinZang (Xi'an Jiaotong University)H-Index: 27
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Abstract Mitochondrial dysfunction is associated with obesity-induced cardiac remodelling. Recent research suggests that the cristae are the true bioenergetic components of cells. Acetylcholine (ACh), the major neurotransmitter of the vagus nerve, exerts cardio-protective effects against ischaemia. This study investigated the role of cristae remodelling in palmitate (PA)-induced neonatal rat cardiomyocyte hypertrophy and explored the beneficial effects of ACh. We found loose, fragmented and even...
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