The BLNK adaptor protein has a nonredundant role in human B-cell differentiation

BackgroundExpression of the pre–B-cell receptor (pre-BCR) by pre-BII cells constitutes a crucial checkpoint in B-cell differentiation. Mutations that affect the pre–B-cell receptor result in early B-cell differentiation blockades that lead to primary B-cell immunodeficiencies. BLNK adaptor protein has a key role in the pre–B-cell receptor signaling cascade, as illustrated by the abnormal B-cell development in the 4 patients with BLNK gene...