Claudine Schiff
Aix-Marseille University
Molecular biologyAntibodyImmunologyB cellBiology
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Publications 99
#1Marielle Balzano (AMU: Aix-Marseille University)H-Index: 1
#2Maria De Grandis (AMU: Aix-Marseille University)H-Index: 5
Last. Stéphane J. C. Mancini (AMU: Aix-Marseille University)H-Index: 15
view all 22 authors...
Summary In the bone marrow, CXCL12 and IL-7 are essential for B cell differentiation, whereas hematopoietic stem cell (HSC) maintenance requires SCF and CXCL12. Peri-sinusoidal stromal (PSS) cells are the main source of IL-7, but their characterization as a pro-B cell niche remains limited. Here, we characterize pro-B cell supporting stromal cells and decipher the interaction network allowing pro-B cell retention. Preferential contacts are found between pro-B cells and PSS cells, which homogeneo...
3 CitationsSource
#1M. FougereauH-Index: 16
Last. Cécile TonnelleH-Index: 20
view all 13 authors...
#1Isabelle André-Schmutz (French Institute of Health and Medical Research)H-Index: 22
#2Claudine SchiffH-Index: 29
Agammaglobulinemia is a feature of a heterogeneous group of primary B cell immunodeficiencies characterized by the quasi-absence of immunoglobulin production and circulating B cells. It is caused by severe blockades of B cell differentiation in the bone marrow. In most cases, gene mutations affect the first checkpoint in B cell differentiation (provided by the pre-B cell receptor (pre-BCR) expressed by early B cells). The mutations affect either the pre-BCR's structural components or its signali...
#1Jeremy Bonzi (AMU: Aix-Marseille University)H-Index: 2
#2Olivier Bornet (AMU: Aix-Marseille University)H-Index: 11
Last. Latifa Elantak (AMU: Aix-Marseille University)H-Index: 8
view all 10 authors...
Galectin-1 (GAL1) is a secreted protein that binds to glycans and to the pre-B-cell receptor (pre-BCR). Here Bonzi et al. show that pre-BCR binding to GAL1 causes a conformational change in the GAL1 carbohydrate-binding site to inhibit binding to selected glycans.
24 CitationsSource
#1Stéphane J. C. Mancini (AMU: Aix-Marseille University)H-Index: 15
#2Latifa Elantak (AMU: Aix-Marseille University)H-Index: 8
Last. Claudine Schiff (AMU: Aix-Marseille University)H-Index: 7
view all 6 authors...
: Galectin-1 (GAL1) is a pre-B cell receptor (pre-BCR) ligand that induces pre-BCR clustering and leads to efficient pre-B cell proliferation and differentiation in the bone marrow. To study pre-BCR-GAL1 interactions and its functional consequence on the early steps of the B cell development, we combine structural nuclear magnetic resonance (NMR) approaches and B cell biology techniques. NMR is applied to identify the residues involved in pre-BCR-GAL1 interactions by monitoring chemical shift pe...
1 CitationsSource
It has recently been demonstrated that memory B cells can reenter and reengage germinal center (GC) reactions, opening the possibility that multi-hit lymphomagenesis gradually occurs throughout life during successive immunological challenges. Here, we investigated this scenario in follicular lymphoma (FL), an indolent GC-derived malignancy. We developed a mouse model that recapitulates the FL hallmark t(14;18) translocation, which results in constitutive activation of antiapoptotic protein B cel...
40 CitationsSource
#1Chantal Lagresle-Peyrou (Paris V: Paris Descartes University)H-Index: 13
#2Michèle Millili (AMU: Aix-Marseille University)H-Index: 1
Last. Claudine Schiff (AMU: Aix-Marseille University)H-Index: 7
view all 11 authors...
Background Expression of the pre–B-cell receptor (pre-BCR) by pre-BII cells constitutes a crucial checkpoint in B-cell differentiation. Mutations that affect the pre–B-cell receptor result in early B-cell differentiation blockades that lead to primary B-cell immunodeficiencies. BLNK adaptor protein has a key role in the pre–B-cell receptor signaling cascade, as illustrated by the abnormal B-cell development in the 4 patients with BLNK gene defects reported to date. However, the BLNK protein's pr...
10 CitationsSource
#1Julie Tellier (AMU: Aix-Marseille University)H-Index: 13
#2Cédric MénardH-Index: 20
Last. Karin TarteH-Index: 44
view all 10 authors...
Follicular Lymphoma (FL) is a B-cell neoplasm resulting from the transformation of germinal center (GC) B cells. Although t(14;18) and ectopic BCL2 expression constitute the genetic hallmark of FL, t(14;18)(pos) B cells bearing genotypic and phenotypic features of FL cells can be found in the blood of most healthy individuals. Nevertheless, the localization of these FL-like cells (FLLC) in non-malignant GC-rich tissues and the functional consequences of BCL2 overexpression have not been evaluate...
29 CitationsSource
#1Adrienne Anginot (AMU: Aix-Marseille University)H-Index: 10
#2Marion Espeli (University of Cambridge)H-Index: 18
Last. Claudine Schiff (AMU: Aix-Marseille University)H-Index: 7
view all 5 authors...
Galectin-1 (GAL1) is an S-type lectin with multiple functions, including the control of B cell homeostasis. GAL1 expression was reported to be under the control of the plasma cell master regulator BLIMP-1. GAL1 was detected at the protein level in LPS-stimulated B cells and was shown to promote Ig secretion in vitro. However, the pattern of GAL1 expression and function of GAL1 in B cells in vivo are still unclear. In this study, we show that, among B cells, GAL1 is only expressed by differentiat...
22 CitationsSource
#1Nathalie Jouve (AMU: Aix-Marseille University)H-Index: 5
#2Nicolas Despoix (AMU: Aix-Marseille University)H-Index: 5
Last. Aurélie S. Leroyer (AMU: Aix-Marseille University)H-Index: 7
view all 10 authors...
CD146 is a highly glycosylated junctional adhesion molecule, expressed on human vascular endothelial cells and involved in the control of vessel integrity. Galectin-1 is a lectin produced by vascular cells that can binds N- and O-linked oligosaccharides of cell membrane glycoproteins. Because both CD146 and Galectin-1 are involved in modulation of cell apoptosis, we hypothesized that Galectin-1 could interact with CD146, leading to functional consequences in endothelial cell apoptosis. We first ...
34 CitationsSource