Effect of doses and dosage forms on the bioavailability of amoxicillin in non-fasted rats
Published on Jan 1, 2012in Journal of Drug Delivery Science and Technology2.606
· DOI :10.1016/S1773-2247(12)50098-5
The absorption of amoxicillin (AMX) administered orally was studied in non-fasted rats. The rats received 15 and 50 mg/kg of AMX in two dosage forms, a suspension and a solution. Plasma concentrations of AMX were determined by HPLC. When AMX was administered at 15 mg/kg, there was no significant difference in C max , T max , AUC and MRT values between the dosage forms. No significant difference in C max , T max , AUC 0 -24h , and MRT 0 -24h was observed at 50 mg/kg either. However, the mean plasma concentration at 12 h of the solution was larger than those of the suspension. The difference was considered to be caused by an inadvertent scattering of the data. The AUC 0 -24h , values at 50 mg/kg were 3.17 times larger than those at 15 mg/kg for the solution, and 3.44 times larger for the suspension. A comparison with AUC values in fasted rats reported previously revealed the bioavailability of AMX to decrease due to the effect of food.