Effect of doses and dosage forms on the bioavailability of amoxicillin in non-fasted rats

The absorption of amoxicillin (AMX) administered orally was studied in non-fasted rats. The rats received 15 and 50 mg/kg of AMX in two dosage forms, a suspension and a solution. Plasma concentrations of AMX were determined by HPLC. When AMX was administered at 15 mg/kg, there was no significant difference in Cmax, Tmax, AUC and MRT values between the dosage forms. No significant difference in Cmax, Tmax , AUC0 -24h , and MRT0 -24h was observed...