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Yoshiharu Machida
Hoshi University
Organic chemistryChemistryChromatographyBiochemistryDosage form
207Publications
38H-index
4,938Citations
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Publications 204
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Lactoferrin (LF) is known to show various useful biological features such as antimicrobial, antiviral, antitumor and anti-inflammatory effects. However, orally administered LF undergoes enzymatic degradation in the gastrointestinal tract, resulting in extensive decrease of such functions. The purpose of this study is to develop a useful oral delivery system of LF. Also, chitosan (Ch) was adopted as a carrier because it is yielded abundantly and a safe polymer. LF-loaded Ch microparticles were pr...
1 CitationsSource
#1Mai KuboderaH-Index: 1
#2Tadakazu Tokumura (International University of Health and Welfare)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
view all 3 authors...
Abstract In the eradication therapy of Helicobacter pylori changes of antibiotics as these concentrations or amount in the stomach after oral administration were not clear. A simple and accurate method for determining the concentration of metronidazole (MTZ) in homogenate of rat stomach was developed in order to obtain basic data to design a pharmaceutical preparation having targeting ability to the surface of gastric-mucosa. This method included a deproteinization process by methanol, separatio...
7 CitationsSource
#1Hiraku OnishiH-Index: 24
#2Yu ImuraH-Index: 1
Last. Yoshiharu MachidaH-Index: 38
view all 4 authors...
Purpose: The potential of sucrose fatty acid esters (SEs) to enhance intestinal absorption was investigated in order to identify their utility for the intestinal absorption of water-soluble high molecular weight compounds. Methods: Fluorescein isothiocyanate-labeled dextran (FD) with a molecular weight (MW) of 4,000 (FD-4) was used as a model compound, and several SEs were tested as absorption enhancers. After FD-4 was administered intra-duodenally at 10 % (w/v) with the non-loop method in situ ...
6 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Hisashi Kikuchi (Hoshi University)H-Index: 2
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
view all 3 authors...
Objective: Simple Eudragit microparticles loaded with prednisolone and chitosan-succinyl-prednisolone conjugate microparticles coated with Eudragit were prepared and characterized in vitro in order to obtain their basic features as a colonic delivery system.Materials and methods: Both types of microparticles were prepared by the emulsification-solvent evaporation modified somewhat from the previous one. Their particle size, shape and their drug content were investigated, and in vitro release pro...
5 CitationsSource
#1T. Tokumura (International University of Health and Welfare)H-Index: 1
#2M. Nagaoka (Hoshi University)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
view all 3 authors...
The absorption of amoxicillin (AMX) administered orally was studied in non-fasted rats. The rats received 15 and 50 mg/kg of AMX in two dosage forms, a suspension and a solution. Plasma concentrations of AMX were determined by HPLC. When AMX was administered at 15 mg/kg, there was no significant difference in C max , T max , AUC and MRT values between the dosage forms. No significant difference in C max , T max , AUC 0 -24h , and MRT 0 -24h was observed at 50 mg/kg either. However, the mean plas...
Source
#1Kazuya HayashiH-Index: 1
#2Masanaho SasatsuH-Index: 10
Last. Hiraku OnishiH-Index: 24
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4 CitationsSource
#1Osamu Sakata (Hoshi University)H-Index: 6
#2Yoshiharu Machida (Hoshi University)H-Index: 38
Last. Hiraku Onishi (Hoshi University)H-Index: 14
view all 3 authors...
Background: In order to obtain an alternative to the intravenous (i.v.) dosage form of clonazepam (CZ), an oral droplet formulation of CZ was developed previously; however, the droplet was physically unstable. Therefore, in the present study, it was attempted to develop an easily-handled dosage form, which was more physically stable and allowed rapid drug absorption from oral mucosa. Method: A semi-solid dosage form, composed of polyethylene glycol 1500 (PEG), CZ, and oleic acid (OA) at 37/1/2 (...
4 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Yuta Saito (Hoshi University)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
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Recently, many people have developed rheumatoid arthritis (RA), and prednisolone (PD) is often used for treatment; however, long use and a large dose of PD can cause toxic side effects. In this study, in order to enhance the therapeutic effects and to suppress the toxic side effects, the conjugate (GC–SP) was prepared by coupling between glycol-chitosan (GC) and succinyl-prednisolone (SP). The drug-release properties of GC–SP were examined and analyzed kinetically. The plasma concentration–time ...
10 CitationsSource
#1T. Tokumura (International University of Health and Welfare)H-Index: 1
#2M. Nagaoka (Hoshi University)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
view all 3 authors...
The absorption of amoxicillin (AMX) administered orally was studied in rats. Male Sprague-Dawley rats received 7, 15, 25 and 50 mg/kg of AMX in two dosage forms, a suspension and a solution. Plasma concentrations of AMX were determined by HPLC. When AMX was administered at 7 mg/kg, there was no significant difference in C max , T max , AUC and MRT values between the dosage forms. At 50 mg/kg, there was no significant difference in the plasma concentrations of AMX, but the C max and AUC values of...
1 CitationsSource
#1Takashi MasutomiH-Index: 2
#2Hiraku OnishiH-Index: 24
Last. Yoshiharu MachidaH-Index: 38
view all 4 authors...
Ovalbumin (OVA) is often used as a model antigen, and its biodistribution is important for the induction of immunization, especially oral immunization. In this study, an allergic substance-detecting kit, Egg Protein ELISA kit, was applied to the investigation of the biodistribution of fluorescein isothiocyanate-labeled ovalbumin (FITC-OVA). After FITC-OVA solution and its double liposomes were administered into the intestinal loop with one Peyers patch, the biodistribution of FITC-OVA was examin...
2 CitationsSource
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