Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
Abstract
Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates factor V activation, completely abrogates the...
Paper Details
Title
Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
Published Date
Jun 21, 2012
Journal
Volume
119
Issue
25
Pages
5972 - 5979
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