Clearance of Amyloid-β Peptide Across the Choroid Plexus in Alzheimers Disease

Aging and several neurodegenerative diseases bring about changes in the anatomy and physiology of the choroid plexus. The identification of specific membrane receptors that bind and internalize extracellular ligands has revolutionized the traditional roles of this tissue. Amyloid beta peptide (Aβ), the major constituent of the amyloid core of senile plaques in patients with Alzheimers disease (AD) is known to contribute to disease neuropathology...