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Eva Carro
Cajal Institute
103Publications
34H-index
4,819Citations
Publications 103
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#1Irene Martínez de Toda (Complutense University of Madrid)H-Index: 6
#2Lara Miguélez (Complutense University of Madrid)
Last.Mónica De la Fuente (Complutense University of Madrid)H-Index: 39
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In Parkinson’s Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in h...
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#1Fernando BartoloméH-Index: 25
Last.Eva CarroH-Index: 34
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The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood–brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an Alzheimer’s disease (AD) model (in APP/PS1 mice). The objective of this study was to investigate the neurogenic and cellular effects of oral administration of S14 on amyloid β (Aβ) overload. We orally administered the PDE7 inhibitor S14 (15 mg/kg/day) or vehicle in 6-mon...
10 CitationsSource
#2Teresa DíazH-Index: 1
Last.Eva CarroH-Index: 34
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Platelets are considered a good model system to study a number of elements associated with neuronal pathways as they share biochemical similarities. Platelets represent the major source of amyloid-β (Aβ) in blood contributing to the Aβ accumulation in the brain parenchyma and vasculature. Peripheral blood platelet alterations including cytoskeletal abnormalities, abnormal cytoplasmic calcium fluxes or increased oxidative stress levels have been related to Alzheimer’s disease (AD) pathology. Ther...
1 CitationsSource
#1Fernando Bartolomé (UCL Institute of Neurology)H-Index: 10
#2Noemí Esteras (UCL Institute of Neurology)H-Index: 12
Last.Andrey Y. Abramov (UCL Institute of Neurology)H-Index: 49
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1 CitationsSource
#1Miren Ettcheto (University of Barcelona)H-Index: 11
#2Elena Sánchez-López (University of Barcelona)H-Index: 9
Last.Antoni Camins (University of Barcelona)H-Index: 40
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There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging are risk factors for the development of Alzheimer’s disease (AD). However, the molecular mechanisms through which obesity interacts with β-amyloid (Aβ) to promote cognitive decline remains poorly understood. Memantine (MEM), a N-methyl-d-aspartate receptor antagonist, is currently used for the treatment of AD. Nonetheless, few studies have reported its effects on genetic preclinical models of this ne...
5 CitationsSource
#1Patricia del Cerro (CSIC: Spanish National Research Council)H-Index: 1
#2Carolina Alquézar (CSIC: Spanish National Research Council)H-Index: 8
Last.Ángeles Martín-Requero (CSIC: Spanish National Research Council)H-Index: 15
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Background Alzheimer’s disease is a multifactorial disorder for which there is no disease-modifying treatment yet. CB2 receptors have emerged as a promising therapeutic target for Alzheimer’s disease because they are expressed in neuronal and glial cells and their activation has no psychoactive effects.
2 CitationsSource
#1Miren Ettcheto (University of Barcelona)H-Index: 11
#2Sonia Abad (University of Barcelona)H-Index: 10
Last.Antoni Camins (University of Barcelona)H-Index: 40
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The molecular basis of memory loss in Alzheimer’s disease (AD), the main cause of senile dementia, is under investigation. In the present study, we have focused on the early hippocampal memory-related changes in APPswe/PS1dE9 (APP/PS1) mice, a well-established mouse model of familial AD. It is well known that molecules like cAMP response element binding (CREB) and binding protein (CBP) play a crucial role in memory consolidation. We analyzed CBP on its transcriptional activity and protein levels...
8 CitationsSource
#2Desiree AntequeraH-Index: 15
Last.Eva CarroH-Index: 34
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Neurogenesis in the adult hippocampus is a unique process in neurobiology that requires functional integration of newly generated neurons, which may disrupt existing hippocampal network connections and consequently loss of established memories. As neurodegenerative diseases characterized by abnormal neurogenesis and memory dysfunctions are increasing, the identification of new anti-aging drugs is required. In adult mice, we found that melatonin, a well-established neurogenic hormone, and the mel...
1 CitationsSource
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