Review paper
Toxic effects of dopamine metabolism in Parkinson's disease
Abstract
Levodopa is the most effective medication for Parkinson's disease (PD). In contrast, there is evidence that levodopa and its metabolites such as dopa/dopamine quinone are toxic for nigral neurons based on in vitro studies. Moreover, there is growing evidence that oxidative stress and mitochondrial dysfunction contribute the pathogenesis of PD. Thus, studies for oxidative stress give us good information for elucidating the pathogenesis of PD. In...
Paper Details
Title
Toxic effects of dopamine metabolism in Parkinson's disease
Published Date
Jan 1, 2009
Volume
15
Pages
S35 - S38
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