Parkinsonism & Related Disorders
Papers 8010
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#1Ali Shoeibi (MUMS: Mashhad University of Medical Sciences)H-Index: 8
#2Irene Litvan (UCSD: University of California, San Diego)H-Index: 79
Last.Joseph Jankovic (BCM: Baylor College of Medicine)H-Index: 132
view all 13 authors...
Abstract The International Parkinson Disease and Movement Disorder Society PSP study group (IPMDS-PSP) recently published new clinical diagnostic criteria for progressive supranuclear palsy (PSP). Currently, there is no data regarding the accuracy of these sets of criteria for differentiating various PSP phenotypes. We discuss the accuracy of the IPMDS-PSP criteria for differentiation of patients with the PSP- Richardson phenotype (PSP-RS) from those with the PSP-Parkinsonism (PSP-P) using data ...
1 CitationsSource
#1Davide Cappon (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 3
#2Mazda BeigiH-Index: 9
Last.Marjan Jahanshahi (University of Electronic Science and Technology of China)H-Index: 62
view all 17 authors...
Abstract Introduction In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS. Methods Patients were assessed at basel...
#1Salvatore Nigro (Magna Græcia University)H-Index: 11
#2Gaetano Barbagallo (Magna Græcia University)H-Index: 9
Last.Giuseppe Lucio Cascini (Magna Græcia University)H-Index: 14
view all 9 authors...
Abstract Introduction Track density imaging (TDI) has been proven to be a useful approach able to investigate white matter (WM) anatomical integrity in several neurodegenerative conditions, such as Parkinson's disease (PD) and classical phenotype of Progressive Supranuclear Palsy (PSP) also known as Richardson's syndrome (RS). To the best of our knowledge, no studies have assessed WM changes in PSP-predominant parkinsonism (PSP–P) patients by using a TDI approach, and no studies have explored th...
#1Kuncheng Liu (Sichuan University)
#2Ruwei Ou (Sichuan University)H-Index: 11
Last.Hui-Fang Shang (Sichuan University)H-Index: 24
view all 8 authors...
Abstract Introduction Pisa Syndrome (PS) is a disabling complication in Parkinson's disease (PD) with unclear pathogenesis, yet studies on the longitudinal observation of PS are absent. This study aims to investigate the clinical predictors of PS from a cohort of Chinese PD patients. Methods A total of 373 PD patients without PS were prospectively monitored for approximately 2.5 years. Demographic and clinical data were investigated. A penalized logistic regression model was conducted to discrim...
#1Hee-Jin Kim (Konkuk University)H-Index: 37
#2Beom S. Jeon (SNU: Seoul National University)H-Index: 32
Abstract Deep brain stimulation (DBS) typically has been delayed until late stage of Parkinson's disease (PD), a mean of 14–15 years after diagnosis. EARLYSTIM study applied DBS in patients with PD presenting motor complications for less than three years, and showed that early stimulation offered greater benefit than best medical therapy in all primary and major secondary end points. Based on the results of EARLYSTIM study, the U.S. Food and Drug Administration recently approved DBS for use in p...
#1Ryul Kim (SNU: Seoul National University)H-Index: 7
#2Beom S. Jeon (SNU: Seoul National University)H-Index: 32
Abstract Advances in diagnostic technologies have revolutionized the field of neurology. There is no doubt that such technologies in clinical practice can hold great promise to improve the diagnosis of movement disorders. However, our concern in the era of diagnostic tests is that clinicians become too dependent on the tests without proper consideration of the clinical context. No matter how excellent a diagnostic test itself is, it is a different matter in clinical practice whether the test enh...
#1V.J. Geraedts (LUMC: Leiden University Medical Center)H-Index: 1
#2Jacobus J. van Hilten (LUMC: Leiden University Medical Center)H-Index: 56
Last.M.F. Contarino (LUMC: Leiden University Medical Center)H-Index: 1
view all 8 authors...
Abstract Objective Although subthalamic Deep Brain Stimulation (STN DBS) is proven effective in improving symptoms of Parkinson's Disease (PD), previous literature demonstrates a discrepancy between objective improvement and patients' perception thereof. We aimed to examine whether postoperative stimulation challenge tests (SCT) alters patients' satisfaction after STN DBS for PD. Methods Fifty-four PD patients underwent preoperative levodopa challenge tests and were routinely invited for SCT 1-2...
#1Olga Gavriliuc (CAU: University of Kiel)
#2Steffen Paschen (CAU: University of Kiel)H-Index: 6
Last.Günther Deuschl (CAU: University of Kiel)H-Index: 85
view all 6 authors...
Abstract Objective Two strategies are known for turning while walking: step turns (the direction change is performed with 3 steps or more) and spin turns (turning on one/both feet simultaneously). It is unknown which strategy patients with Parkinson's disease (PD) choose and if l -dopa and STN-DBS are influencing this strategy. Methods Video-recordings of 171 PD patients that completed 180° turns were analyzed by two blinded raters before surgery, both off and on l -dopa, and one year after STN-...
#1Martina Mancini (OHSU: Oregon Health & Science University)H-Index: 29
#2Katherine Chung (OHSU: Oregon Health & Science University)H-Index: 1
Last.John G. Nutt (OHSU: Oregon Health & Science University)H-Index: 80
view all 8 authors...
Abstract Introduction Degeneration of cholinergic systems may contribute to impairments of balance and gait in Parkinson's disease (PD) and phase 2 clinical trials have suggested that centrally acting cholinesterase inhibitors reduce falls. Here, we examined the effects of augmenting cholinergic neurotransmission on static and dynamic balance, indices of fall risk. Methods A single-site, randomized, double-blind, crossover trial examined the effect of donepezil in patients with PD. Forty-nine pa...
Abstract Introduction Elevated temporal discrimination thresholds (TDT) have been found in cervical dystonia (CD) and unaffected first-degree relatives, indicating autosomal dominant inheritance with reduced penetrance, serving as an endophenotype and being indicative of abnormal inhibitory processing within the brainstem-basal ganglia circuits. The blink reflex R2 recovery cycle (BRRC) is also a measure of excitability of brainstem-basal ganglia circuits, and inconsistent findings are reported ...
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