Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy
Abstract
Aβ immunotherapy for Alzheimer’s disease (AD) results in the removal of Aβ plaques and increased cerebral amyloid angiopathy (CAA). In current clinical trials, amyloid-related imaging abnormalities (ARIAs), putatively due to exacerbation of CAA, are concerning side effects. We aimed to assess the role of the Aβ transporter apolipoprotein E (apoE) in the exacerbation of CAA and development of CAA-associated vasculopathy after Aβ immunotherapy. 12...
Paper Details
Title
Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy
Published Date
Sep 7, 2014
Journal
Volume
128
Issue
6
Pages
777 - 789
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