Original paper
Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions
Abstract
Aging in the brain is characterized by increased susceptibility to neuronal loss and functional decline, and mitochondrial DNA (mtDNA) mutations are thought to play an important role in these processes. Due to the proximity of mtDNA to the main sites of mitochondrial free radical generation, oxidative stress is a major source of DNA mutations in mitochondria. The base excision repair (BER) pathway removes oxidative lesions from mtDNA, thereby...
Paper Details
Title
Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions
Published Date
Jun 1, 2010
Journal
Volume
31
Issue
6
Pages
993 - 1002
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Notes
History