Effect of toluidines and dinitrotoluenes on caffeine metabolic ratio in rat
Abstract
Caffeine (1,3,7-trimethylxanthine, CA) is metabolised by N-demethylation to three primary metabolites: theophylline (TP), paraxanthine (PX) and theobromine (TB). This process is mediated in 95% by CYP1A2. Thus the measurement of CA demethylated metabolites can be used as a marker of CYP1A2 activity in vivo. In the present study, caffeine and its primary metabolites were determined simultaneously in plasma of rats pretreated with three isomers of...
Paper Details
Title
Effect of toluidines and dinitrotoluenes on caffeine metabolic ratio in rat
Published Date
Jan 1, 1999
Journal
Volume
104
Issue
1-2
Pages
159 - 165
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