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Toxicology Letters
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Last. Márcia Carvalho (University of Porto)H-Index: 31
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Abstract Synthetic cathinones abuse remains a serious public health problem. Kidney injury has been reported in intoxications associated with synthetic cathinones, but the molecular mechanisms involved have not been explored yet. In this study, the potential in vitro nephrotoxic effects of four commonly abused cathinone derivatives, namely pentedrone, 3,4-dimethylmethcatinone (3,4-DMMC), methylone and 3,4-methylenedioxypyrovalerone (MDPV), were assessed in the human kidney HK-2 cell line. All fo...
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#1Haidi Huang (Binzhou University)H-Index: 2
#2Xin Wang (Binzhou University)
Last. Wanglin Jiang (Binzhou University)H-Index: 14
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Abstract Roxadustat is the first orally administered, small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that has been submitted for FDA regulatory approval to treat anemia secondary to chronic kidney diseases. Its usage has also been suggested for pulmonary fibrosis; however, the corresponding therapeutic effects remain to be investigated. The in vitro effects of roxadustat on cobalt chloride (CoCl2)-stimulated pulmonary fibrosis with L929 mouse fibroblasts as well as on...
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#1Weijian Zhang (SYSU: Sun Yat-sen University)
#2Hao Xiong (SYSU: Sun Yat-sen University)H-Index: 8
Last. Yiqing Zheng (SYSU: Sun Yat-sen University)H-Index: 12
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Abstract Cisplatin is a well-known and commonly used chemotherapeutic agent. However, cisplatin-induced ototoxicity limits its clinical use. Previous studies have shown an important role of reactive oxygen species (ROS) accumulation in the pathogenesis of cisplatin-induced ototoxicity. In many cell types, the transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) protect against oxidative stress by suppressing ROS. Here our results showed ...
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Abstract The objective of this study is to highlight the effectiveness of urinary lead as an index of recent lead exposure. In the past scientific literature urinary lead has been studied as a parameter for recent lead exposure. It is a reliable indicator for occupational lead exposure. But, strangely enough, nowadays is scarcely used in the Netherlands and worldwide. We performed six field biological monitoring studies of preshift and postshift urinary lead tests during tank maintenance and bri...
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#1Tingting Liu (Jiangsu University)H-Index: 1
#2Qianqian Gao (Jiangsu University)
Last. Yubin ZhangH-Index: 1
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Abstract Hypoxia-inducible factor 1 (HIF-1) is a critical nuclear transcription factor for adaptation to hypoxia; its regulatable subunit, HIF-1α, is a cytoprotective regulatory factor. We examined the effects of methylmercury (MeHg) in rat adrenal pheochromocytoma (PC12) cells and the rat hepatocyte cell line BRL. MeHg treatment led to time- and concentration-dependent toxicity in both lines with statistically significant cytotoxic effects at 5 µM and 10 µM in PC12 and BRL, respectively, at 0.5...
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#1Weifeng Lan (Fujian Medical University)
#2Zhijian Chen (Fujian Medical University)
Last. Yongbiao Chen (Fujian Medical University)
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Abstract Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after cholestasis. However, the mechanism underlying GCDCA-induced hepatotoxicity remains unclear. In this study, we found that GCDCA inhibits autophagosome formation and impairs lyso...
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#1Héléna Alamil (UNICAEN: University of Caen Lower Normandy)H-Index: 1
#2Laurence GalantiH-Index: 1
Last. Mathilde Lechevrel (UNICAEN: University of Caen Lower Normandy)H-Index: 10
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Abstract Electrophilic compounds present in humans, originating from endogenous processes or pollutant exposures, pose a risk to health though their reaction with nucleophilic sites in protein and DNA. Among this chemical class, aldehydes are mainly present in indoor air and they can also be produced by endogenous lipid peroxidation arising from oxidative stress. Known to be very reactive, aldehydes have the ability to form exocyclic adducts to DNA that, for the most if not repaired correctly, a...
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#1L. Hernández-Gutiérrez (UNAM: National Autonomous University of Mexico)
#2Rafael Camacho-Carranza (UNAM: National Autonomous University of Mexico)H-Index: 12
Last. J.J. Espinosa-Aguirre (UNAM: National Autonomous University of Mexico)H-Index: 8
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Abstract The Cytochrome P450 (CYP) enzyme family comprises a wide array of monooxygenases involved in the oxidation of endobiotic and xenobiotic molecules. The active site of a CYP enzyme contains an iron protoporphyrin center coordinated to a cysteine thiolate, and then, molecular oxygen is associated with the iron to be converted into dioxygen complex plus substrate. Reduction by CYP reductase expedites hydroxylation of the compound. In this oxidation reaction, insufficient oxygen molecules wo...
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#1Wu Yao (Zhengzhou University)H-Index: 5
#2Mingcui Ding (Zhengzhou University)H-Index: 4
Last. Changfu Hao (Zhengzhou University)H-Index: 3
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Abstract Improvements in science and technology have led to the increasing threats of new chemicals to the public health. It is crucial to evaluate the toxicity, especially immunotoxicology. Dendritic cells (DCs) are believed to be more favorable choices in immunotoxicity evaluations. To obtain and evaluate the value of human monocyte-derived immature DCs (imDCs) in vitro applications in immunotoxicology, compared the results in vitro. DCs were obtained from enriched leukocytes of peripheral blo...
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#1Cynthia V. Rider (NIH: National Institutes of Health)H-Index: 9
#2Molly Vallant (NIH: National Institutes of Health)H-Index: 10
Last. Katie J. Turner (RTP: Research Triangle Park)H-Index: 4
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Abstract N-Butylbenzenesulfonamide (NBBS) is a plasticizer and emerging contaminant that has been detected in a wide array of environmental samples. There are very little toxicity data available with which to evaluate potential risk from exposure to NBBS or other structurally-related sulfonamide plasticizers. To address this knowledge gap, NBBS was selected by the National Toxicology Program for evaluation. The current short-term pre- and post-natal (perinatal) study aims to provide preliminary ...
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