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Toxicology Letters
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3.50
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Papers 23946
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#1Yue Xi (SYSU: Sun Yat-sen University)H-Index: 2
#2Yunhui Zhang (SYSU: Sun Yat-sen University)
Last.Zhiying Huang (SYSU: Sun Yat-sen University)H-Index: 15
view all 7 authors...
Abstract Triptolide (TP), a principal bioactive component extracted from traditional Chinese medicine Tripterygium wilfordii Hook. F. (TWHF), has attracted wide attention of its therapeutic effects on inflammation and autoimmune diseases. However, the therapeutic application of TP is hindered by severe cardiomyocyte toxicity and narrow therapeutic window. We previously identified that the p53 was an indispensable contributor in TP-induced myocardial injury. p53 has an inhibitory effect on IKKβ-N...
#1Mariana T. Farcas (WVU: West Virginia University)H-Index: 7
#2Aleksandr B. Stefaniak (NIOSH: National Institute for Occupational Safety and Health)H-Index: 24
Last.Yong Qian (NIOSH: National Institute for Occupational Safety and Health)H-Index: 29
view all 16 authors...
Abstract During extrusion of some polymers, fused filament fabrication (FFF) 3-D printers emit billions of particles per minute and numerous organic compounds. The scope of this study was to evaluate FFF 3-D printer emission-induced toxicity in human small airway epithelial cells (SAEC). Emissions were generated from a commercially available 3-D printer inside a chamber, while operating for 1.5 h with acrylonitrile butadiene styrene (ABS) or polycarbonate (PC) filaments, and collected in cell cu...
#1Mike A. MojicaH-Index: 1
#2Melissa D. CarterH-Index: 8
Last.Rudolph C. JohnsonH-Index: 11
view all 10 authors...
Abstract In 2017, the U.S. Department of Health and Human Services and the White House declared a public health emergency to address the opioid crisis ( Hargan, 2017 ). On average, 192 Americans died from drug overdoses each day in 2017; 130 (67%) of those died specifically because of opioids ( Scholl et al., 2019 ). Since 2013, there have been significant increases in overdose deaths involving synthetic opioids – particularly those involving illicitly-manufactured fentanyl. The U.S. Drug Enforc...
#1Gongchang Yu (SDU: Shandong University)H-Index: 4
#2Yu Zhang (Academy of Medical Sciences, United Kingdom)H-Index: 1
Last.Hua Shao (Academy of Medical Sciences, United Kingdom)H-Index: 5
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Abstract Toluene-diisocyanate (TDI) is mainly used in the manufacturing process of polyurethane foams, and is a potent inducer of occupational asthma characterized by airway inflammation and airway hyperreactivity. Thymic stromal lymphopoietin (TSLP) plays an important role in the development of asthma, and correlating with the differentiation of Th2 and Th17 cells. However, the role of TSLP in TDI-induced asthma remains unclear. In this study, 96 TDI-exposed workers as well as a mouse model of ...
#1Isaac K. Sundar (URMC: University of Rochester Medical Center)H-Index: 29
#2Krishna P. Maremanda (URMC: University of Rochester Medical Center)
Last.Irfan Rahman (URMC: University of Rochester Medical Center)H-Index: 81
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Abstract Cigarette smoke (CS) is known to cause mitochondrial dysfunction leading to cellular senescence in lung cells. We determined the mechanism of mitochondrial dysfunction by CS in lung epithelial cells. CSE treatment differentially affected mitochondrial function, such as membrane potential, mitochondrial reactive oxygen species (mtROS) and mitochrondrial mass as analyzed by FACS, and were associated with altered oxidative phosphorylation (OXPHOS) proteins levels (Complexes I-IV) in primar...
#1Yosuke Iyama (University of Shizuoka)H-Index: 1
#2Hideyuki Sato (University of Shizuoka)H-Index: 13
Last.Satomi Onoue (University of Shizuoka)H-Index: 27
view all 4 authors...
Abstract This study involved an attempt to establish a new photosafety screening system for dermally-applied chemicals consisting of a reactive oxygen species (ROS) assay and an in vitro skin permeation test. The ROS assay was undertaken to evaluate photoreactivity of six test compounds, acridine (ACD), furosemide (FSM), hexachlorophene (HCP), 8-methoxypsoralen (MOP), norfloxacin (NFX), and promethazine (PMZ), and the in vitro skin permeation test was conducted to obtain steady-state concentrati...
#1Lin-xin Pan (Anhui Medical University)H-Index: 2
#2Liang-yun Li (Anhui Medical University)H-Index: 1
Last.Tao Xu (Anhui Medical University)H-Index: 11
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Abstract Recent studies have shown that Transmembrane protein 100 (TMEM100) is a gene at locus 17q32 encoding a 134-amino acid protein with two hypothetical transmembrane domainsa, and first identified as a transcript from the mouse genome. As a downstream target gene of bone morphogenetic protein (BMP)-activin receptor-like kinase 1 (ALK1) signaling, it was activated to participate in inducing arterial endothelium differentiation, maintaining vascular integrity, promoting cell apoptosis, inhibi...
#1Feng Wang (Anhui Medical University)H-Index: 5
#2Li-ping Huang (Anhui Medical University)
Last.Qi-xing Zhu (Anhui Medical University)H-Index: 10
view all 7 authors...
Abstract Trichloroethylene (TCE), a commonly used industrial solvent and degreasing agent, is known to cause trichloroethylene hypersensitivity syndrome (THS) with multi-system damage, including skin, liver and kidney. Clinical evidence have shown that the kidney injury occurs in THS and our previous studies suggested that the terminal complement complex C5b-9 deposited in impaired renal tubules induced by TCE with unclear mechanisms. In the present study, we questioned whether activation of the...
#1Yi-Fan Chen (LSU: Louisiana State University)H-Index: 3
#2Tammy R. Dugas (LSU: Louisiana State University)H-Index: 17
Abstract Combination antiretroviral therapy (cART) has been hugely successful in reducing the mortality associated with human immunodeficiency virus (HIV) infection, resulting in a growing population of people living with HIV (PLWH). Since PLWH now have a longer life expectancy, chronic comorbidities have become the focus of the clinical management of HIV. For example, cardiovascular complications are now one of the most prevalent causes of death in PLWH. Numerous epidemiological studies show th...
#1Anthony M. Fletcher (BMS: Bristol-Myers Squibb)H-Index: 3
#2Pierre Tellier (Charles River Laboratories)H-Index: 1
Last.William E. Achanzar (BMS: Bristol-Myers Squibb)H-Index: 8
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Abstract PEGylation is considered a safe mechanism to enhance the pharmacokinetics (PK) and pharmacodynamics (PD) of biotherapeutics. Previous studies using PEGylation as a PK enhancement tool have reported benign PEG-related vacuolation in multiple tissues. This paper establishes a threshold for PEG burden beyond which there are alterations in tissue architecture that could potentially lead to dysfunction. As part of the nonclinical safety assessment of Compound A, a 12 kDa protein conjugated t...
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