Protocol for the Perfusion and Angiography Imaging Sub-Study of the Third International Stroke Trial (IST-3) of Alteplase Treatment within Six-Hours of Acute Ischemic Stroke

Rationale Intravenous thrombolysis with recombinant tissue Plasminogen Activator improves outcomes in patients treated early after stroke but at the risk of causing intracranial hemorrhage. Restricting recombinant tissue Plasminogen Activator use to patients with evidence of still salvageable tissue, or with definite arterial occlusion, might help reduce risk, increase benefit and identify patients for treatment at late time windows. Aims To...