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Joanna M. Wardlaw
University of Edinburgh
974Publications
89H-index
34.8kCitations
Publications 991
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Abstract Fluctuating body asymmetry is theorized to indicate developmental instability, and to have small positive associations with low socioeconomic status (SES). Previous studies have reported small negative associations between fluctuating body asymmetry and cognitive functioning, but relationships between fluctuating brain asymmetry and cognitive functioning remain unclear. The present study investigated the association between general intelligence (a latent factor derived from a factor ana...
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Using raw structural and diffusion brain MRI data from the UK Biobank (UKB; N = 3,155, ages 45-75 years) and the Lothian Birth Cohort 1936 (LBC1936; N = 534, all age 73 years), we examine aging of regional grey matter volumes (nodes) and white matter structural connectivity (edges) within networks-of-interest in the human brain connectome. In UKB, the magnitude of age-differences in individual node volumes and edge weights corresponds closely with their loadings on their respective principal com...
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DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as...
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 12 authors...
Abstract Introduction We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospati...
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Joanna M. Wardlaw (Edin.: University of Edinburgh)H-Index: 89
view all 15 authors...
Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyper...
2 CitationsSource
#1Nick A. Weaver (UU: Utrecht University)H-Index: 4
#2Lei ZhaoH-Index: 4
Last.Geert Jan Biessels (UU: Utrecht University)H-Index: 51
view all 31 authors...
Abstract Introduction The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility ...
4 CitationsSource
#1Ahmed E. Fetit (Dund.: University of Dundee)
#2Alex S. F. Doney (Dund.: University of Dundee)H-Index: 52
Last.Emanuele Trucco (Dund.: University of Dundee)H-Index: 33
view all 10 authors...
Cardiovascular diseases are a public health concern; they remain the leading cause of morbidity and mortality in patients with type 2 diabetes. Phenotypic information available from retinal fundus images and clinical measurements, in addition to genomic data, can identify relevant biomarkers of cardiovascular health. In this study, we assessed whether such biomarkers stratified risks of major adverse cardiac events (MACE). A retrospective analysis was carried out on an extract from the Tayside G...
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Abstract Background and Purpose Perivascular Spaces (PVS), also known as Virchow-Robin spaces, seen on structural brain MRI, are important fluid drainage conduits and are associated with small vessel disease (SVD). Computational quantification of visible PVS may enable efficient analyses in large datasets and increase sensitivity to detect associations with brain disorders. We assessed the associations of computationally-derived PVS parameters with vascular factors and white matter hyperintensit...
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#1Janie Corley (Edin.: University of Edinburgh)H-Index: 30
#2Simon R. Cox (Edin.: University of Edinburgh)H-Index: 20
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 10 authors...
Recent advances in genome-wide DNA methylation (DNAm) profiling for smoking behaviour have given rise to a new, molecular biomarker of smoking exposure. It is unclear whether a smoking-associated DNAm (epigenetic) score has predictive value for ageing-related health outcomes which is independent of contributions from self-reported (phenotypic) smoking measures. Blood DNA methylation levels were measured in 895 adults aged 70 years in the Lothian Birth Cohort 1936 (LBC1936) study using the Illumi...
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