Joanna M. Wardlaw
University of Edinburgh
PathologyMagnetic resonance imagingPhysical therapyStrokeMedicine
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Publications 1000
#1Philip M.W. BathH-Index: 69
#2Vincent MokH-Index: 45
Last. Martin DichgansH-Index: 81
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#1Zien Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Sohei Yoshimura (The George Institute for Global Health)H-Index: 12
Last. Xiaoying Chen (The George Institute for Global Health)H-Index: 8
view all 18 authors...
Background and Purpose: To determine factors associated with fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-HAs) on magnetic resonance imaging and their prognostic signifi...
#1James W. Madole (University of Texas at Austin)H-Index: 3
#2Stuart J. Ritchie ('KCL': King's College London)H-Index: 26
Last. Ian J. Deary (Edin.: University of Edinburgh)H-Index: 132
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Abstract Background Aging-related cognitive decline is a primary risk factor for Alzheimer’s disease and related dementias. More precise identification of the neurobiological bases of cognitive decline in aging populations may provide critical insights into the precursors of late-life dementias. Methods Using structural and diffusion brain MRI data from the UK Biobank (UKB; N = 8,185, ages 45-78 years), we examined aging of regional grey matter volumes (nodes) and white matter structural connect...
#1Nicola J. Armstrong (Murdoch University)H-Index: 33
#2Karen A. Mather (UNSW: University of New South Wales)H-Index: 32
Last. Nicole D. Dueker (John P. Hussman Institute for Human Genomics)H-Index: 2
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Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first st...
#1Una Clancy (Edin.: University of Edinburgh)
#2Daniela Jaime Garcia (Edin.: University of Edinburgh)H-Index: 1
Last. Gordon W. Blair (Edin.: University of Edinburgh)H-Index: 9
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BackgroundCerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, d...
#1Jose BernalH-Index: 6
Last. Joanna M. WardlawH-Index: 93
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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to examine the distribution of an intravenous contrast agent within the brain. Computational methods have been devised to analyse the contrast uptake/washout over time as reflections of cerebrovascular dysfunction. However, there have been few direct comparisons of their relative strengths and weaknesses. In this paper, we compare five semiquantitative methods comprising the slope and area under the enhancement-time curve...
#1Thomas Gattringer (Edin.: University of Edinburgh)H-Index: 1
#1Thomas Gattringer (Medical University of Graz)H-Index: 16
Last. Joanna M. Wardlaw (Edin.: University of Edinburgh)H-Index: 93
view all 11 authors...
Morphologic evolution of recent small subcortical infarcts (RSSI) ranges from lesion disappearance to lacune formation and the reasons for this variability are still poorly understood. We hypothesized that diffusion tensor imaging (DTI) and blood-brain-barrier (BBB) abnormalities early on can predict tissue damage 1 year after an RSSI. We studied prospectively recruited patients with a symptomatic MRI-defined RSSI who underwent baseline and two pre-specified MRI examinations at 1–3-month and 1-y...
#1Gordon W. BlairH-Index: 9
Last. Fergus N. DoubalH-Index: 31
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Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF pulsatility, and their independent relationship with cerebral small vessel disease (SVD) features in patients with minor ischemic stroke and MRI evidence of SVD. Methods We recruited patients with minor ischemic stroke and assessed CVR using blood oxygen level–dependent MRI during a hypercapnic challenge, cerebral blood flow (CBF), vascular and CSF pulsatility using phase-contrast MRI, and structural magnetic...
1 CitationsSource
#1Anne Biton (Pasteur Institute)H-Index: 10
#1Anne Biton (Paris Diderot University)
Last. Hans J. GrabeH-Index: 57
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#1Gregory Beaudet (University of Bordeaux)H-Index: 1
Last. Reinhold Schmidt (Medical University of Graz)H-Index: 77
view all 26 authors...
: Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and more recently, peak width of skeletonized mean diffusivity (PSMD), have been proposed as potential markers of normal and pathological brain ageing. However, their relative evolution over the entire adult lifespan in healthy individuals remains partly unknown during early and late adulthood, and particularly fo...
1 CitationsSource