Original paper
Nonviral delivery of self-amplifying RNA vaccines
Volume: 109, Issue: 36, Pages: 14604 - 14609
Published: Aug 20, 2012
Abstract
Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine. Here we show that nonviral delivery of a 9-kb self-amplifying RNA encapsulated within an LNP substantially increased immunogenicity...
Figures & Tables
Fig. 1. Characterization of self-amplifying RNA vaccines. (A) Schematic illustra...
Fig. 2. Whole-mouse in vivo bioluminescence imaging after bilateral i.m. injecti...
Fig. 3. Comparative mouse immunogenicity studies of a lipid nanoparticle formula...
Fig. 4. Mouse immunogenicity studies of a lipid nanoparticle formulated self-amp...
Fig. 5. Cotton rat immunogenicity and protection studies of a lipid nanoparticle...
Paper Details
Title
Nonviral delivery of self-amplifying RNA vaccines
Published Date
Aug 20, 2012
Volume
109
Issue
36
Pages
14604 - 14609
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