Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5‐HT)_2A and DA D₂ antagonism and 5‐HT_1A partial agonism

Atypical antipsychotic drugs ( AAPD s) have been suggested to be more effective in improving cognitive impairment in schizophrenia than typical APD s, a conclusion supported by differences in receptor affinities and neurotransmitter efflux in the cortex and the hippocampus. More potent serotonin (5‐ HT ) 2A than dopamine ( DA ) D 2 receptors antagonism, and direct or indirect 5‐ HT 1A agonism, characterize almost all AAPD s. Blonanserin, an AAPD...