Effect of Activation of ATP-Dependent Potassium Channels with (-)-Pinacidil and (-)-3-Pyridyl Pinacidil on Infarct Size in a Canine Model of Ischemia-Reperfusion Injury

We tested the hypothesis that opening myocardial ATP-dependent K + (ATP-K) channels by administration of (-)-pinacidil or (-)-3-pyridyl pinacidil intracoronarily (i.e.) either during ischemia or as pretreatment could decrease infarct size in a canine model of ischemia-reperfusion injury in anesthetized male hounds subjected to 90-min left circumflex coronary artery (LCX) occlusion followed by 5-h reperfusion. Drugs were administered by one of...