Journal of Cardiovascular Pharmacology
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#1C McGinley (Dund.: University of Dundee)
#2Ify Mordi (Dund.: University of Dundee)H-Index: 11
Last. John Irving (Ninewells Hospital)H-Index: 11
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OBJECTIVE Administration of unfractionated heparin to STEMI patients by the ambulance service is established practice in Scotland, but efficacy is unknown. We studied the effects of unfractionated heparin in STEMI patients treated by primary percutaneous coronary intervention (PPCI), on infarct artery patency and mortality. METHODS AND RESULTS Consecutive patients (n=1,000) admitted to Ninewells Hospital, Dundee, from 2010-2014 for PPCI were allocated to two groups: 437 (44%) pre-hospital hepari...
In the recent years the awareness of the role purinergic signaling plays as a therapeutic target has increased considerably. The purinoceptor allows the action of extracellular nucleotides (P2 receptors), as well as intermediary products of their metabolism, such as adenosine (P1 receptors), regulating pivotal processes occurring in the cardiovascular system.This study focuses on a dual purinoreceptor-dependent approach, based on the activation of adenosine P1 receptors with the simultaneous inh...
#1Arturo CesaroH-Index: 4
#2Vittorio Taglialatela (University of Naples Federico II)H-Index: 1
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Prolonged dual antiplatelet therapy (DAPT) after 12 months in patients with prior myocardial infarction is attractive to reduce long-term ischemic complications. In the PEGASUS-TIMI 54, the use of low-dose ticagrelor (60 mg b.i.d.) plus aspirin after 12 months from myocardial infarction reduced the risk of ischemic events, at the price of limited increase on bleeding complications. However, data on the use of low-dose ticagrelor in real-world practice lack. We aim at providing data on prescripti...
#1Arsalan Hamid (UMMC: University of Mississippi Medical Center)
#2Muthiah Vaduganathan (Brigham and Women's Hospital)H-Index: 36
Last. Javed Butler (UMMC: University of Mississippi Medical Center)H-Index: 29
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Sodium-glucose co-transport protein-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been shown to reduce cardiovascular events in high-risk patients with type 2 diabetes mellitus (T2DM). We examined real-world use of these agents at a US academic medical center in the state of Mississippi. Prescriptions, provider specialty, and insurance status of users of SGLT2is and GLP-1RAs in patients with T2DM, and T2DM and cardiovascular disease (CVD) seen from 1 Januar...
#1Guixiang Zhao (XMU: Xinjiang Medical University)
#2Juledezi Hailati (First Affiliated Hospital of Xinjiang Medical University)
Last. Zhiqiang Liu (First Affiliated Hospital of Xinjiang Medical University)
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Myocardial cell death during acute myocardial infarction occurs due to acute ischemia, persistent ischemia, reperfusion associated injury and the inflammatory infiltrate as a response to cell necrosis. In the present study, qPCR showed that lncRNA Gm4419 was highly upregulated in ischemia/reperfusion myocardial tissues and hypoxia/reoxygenation H9C2 cells while miR-682 was downregulated. Knocking down Gm4419 with sh-Gm4419 resulted in the rescue of myocardial infarction and apoptosis induced by ...
#2Guihu Sun (Kunming Medical University)H-Index: 1
Last. Yan Wang (Kunming Medical University)
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Atherosclerosis (AS) is the most common and serious complication in type 2 diabetes mellitus (T2DM). Recent studies have emphasized that inflammation is the main cause of atherosclerosis. Studies have shown that carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) regulates the expression of matrix metallopeptidase 9 (MMP-9) after ischemic stroke to reduce inflammation. The aim of this study was to elucidate potential molecular mechanism of CEACAM1 on the inflammatory response...
Top fields of study
Diabetes mellitus
Blood pressure