Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L.

Published on Oct 1, 2013in Carbohydrate Polymers6.04
· DOI :10.1016/j.carbpol.2013.04.057
Jing Zhu4
Estimated H-index: 4
(CPU: China Pharmaceutical University),
Wenying Liu14
Estimated H-index: 14
(CPU: China Pharmaceutical University)
+ 4 AuthorsXiangdong Gao20
Estimated H-index: 20
(CPU: China Pharmaceutical University)
Abstract Diabetes mellitus is a group of complicated metabolic disorders characterized by high blood glucose level and inappropriate insulin secreting capacity due to decreased glucose metabolism and pancreatic β cell mass or dysfunction of β cells. Thus, improving glucose metabolism and preserving β cell mass and function might be useful for the treatment of diabetes. In this study, a novel acidic polysaccharide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macroporous resin and ion-exchanged column. Monosaccharide composition analysis indicated that LBP-s-1 was comprised of rhamnose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid in the molar ratio of 1.00:8.34:1.25:1.26:1.91:7.05:15.28. The preliminary structure features of LBP-s-1 were investigated by FT-IR, 1 H NMR and 13 C NMR. In vitro and in vivo hypoglycemic experiments showed that LBP-s-1 had significant hypoglycemic effects and insulin-sensitizing activity through increasing glucose metabolism and insulin secretion and promoting pancreatic β cell proliferation. Preliminary mechanisms were also elucidated.
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