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Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L.

Published on Oct 1, 2013in Carbohydrate Polymers6.04
· DOI :10.1016/j.carbpol.2013.04.057
Jing Zhu4
Estimated H-index: 4
(CPU: China Pharmaceutical University),
Wenying Liu14
Estimated H-index: 14
(CPU: China Pharmaceutical University)
+ 4 AuthorsXiangdong Gao20
Estimated H-index: 20
(CPU: China Pharmaceutical University)
Abstract
Abstract Diabetes mellitus is a group of complicated metabolic disorders characterized by high blood glucose level and inappropriate insulin secreting capacity due to decreased glucose metabolism and pancreatic β cell mass or dysfunction of β cells. Thus, improving glucose metabolism and preserving β cell mass and function might be useful for the treatment of diabetes. In this study, a novel acidic polysaccharide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macroporous resin and ion-exchanged column. Monosaccharide composition analysis indicated that LBP-s-1 was comprised of rhamnose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid in the molar ratio of 1.00:8.34:1.25:1.26:1.91:7.05:15.28. The preliminary structure features of LBP-s-1 were investigated by FT-IR, 1 H NMR and 13 C NMR. In vitro and in vivo hypoglycemic experiments showed that LBP-s-1 had significant hypoglycemic effects and insulin-sensitizing activity through increasing glucose metabolism and insulin secretion and promoting pancreatic β cell proliferation. Preliminary mechanisms were also elucidated.
  • References (29)
  • Citations (92)
References29
Newest
#1Evelina L. Zdorovenko (RAS: Russian Academy of Sciences)H-Index: 13
#2Olga A. Valueva (RAS: Russian Academy of Sciences)H-Index: 5
Last.Adam Choma (UMCS: Maria Curie-Skłodowska University)H-Index: 15
view all 7 authors...
#1Yoshihisa Sogame (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
#2Atsushi Kitamura (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
Last.Setsuko Komuro (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 9
view all 4 authors...
#1Ying Wang (CPU: China Pharmaceutical University)H-Index: 9
#2Hongping Yin (CPU: China Pharmaceutical University)H-Index: 11
Last.Min Wang (CPU: China Pharmaceutical University)H-Index: 13
view all 6 authors...
#1C.C. Wang (FJU: Fu Jen Catholic University)H-Index: 2
#2S.C. Chang (FJU: Fu Jen Catholic University)H-Index: 3
Last.B.H. Chen (FJU: Fu Jen Catholic University)H-Index: 38
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Cited By92
Newest
#1Muhammad Saeed Khan (SCUT: South China University of Technology)H-Index: 1
#2Chun Chen (SCUT: South China University of Technology)
Last.Xiong Fu (SCUT: South China University of Technology)H-Index: 27
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#1Dongying Wang (Henan University of Technology)H-Index: 2
#2Chenxi Li (Henan University of Technology)
Last.Yu-Xiang Ma (Henan University of Technology)H-Index: 1
view all 6 authors...
#1Juncheng Chen (SCUT: South China University of Technology)H-Index: 2
#2Xia Zhang (SCUT: South China University of Technology)H-Index: 9
Last.Lin Li (DGUT: Dongguan University of Technology)
view all 8 authors...
#1Kaidong Li (CPU: China Pharmaceutical University)
#2Lingling Zhu (CPU: China Pharmaceutical University)
Last.Wenying Liu (CPU: China Pharmaceutical University)H-Index: 14
view all 7 authors...
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