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Xiangdong Gao
China Pharmaceutical University
PolysaccharideMolecular biologyChemistryBiochemistryBiology
126Publications
20H-index
1,550Citations
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Publications 120
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#1Xuyang Sun (CPU: China Pharmaceutical University)
#2Qianqian Zhao (CPU: China Pharmaceutical University)
Last. Wei Liu (CPU: China Pharmaceutical University)H-Index: 15
view all 7 authors...
Abstract Ethnopharmacological relevance Proteoglycans are one of the active ingredients of great importance in Sarcandra glabra. The biological activities of proteoglycans extracted from Sarcandra glabra including suppressing tumor growth and antioxidant activity were studied. However, raw materials from different regions may cause differences in the activity of natural extracts, especially for bioactive biomacromolecules. Conventional identification of S.glabra cannot accurately reflect the dis...
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#1Yue Tong (CPU: China Pharmaceutical University)H-Index: 5
#2Yu Zhang (CPU: China Pharmaceutical University)H-Index: 1
Last. Wenbing Yao (CPU: China Pharmaceutical University)H-Index: 18
view all 6 authors...
Abstract Impaired vascularization of adipose tissue leads to local hypoxia and results in chronic inflammation and obesity-related metabolic disorders. We have recently constructed an engineered protein named tPep-VEGF-B by bridging vascular endothelial growth factor (VEGF-B) with an adipose-targeted peptide. Here, we reported tPep-VEGF-B diminishes obesity and alleviates metabolic syndrome. High fat diet (HFD) treated mice had reduced adipose vascular density and showed adipose hypoxia and meta...
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#1Weisheng Lu (CPU: China Pharmaceutical University)H-Index: 4
#2Hong Tian (CPU: China Pharmaceutical University)H-Index: 9
Last. Wenbing Yao (CPU: China Pharmaceutical University)H-Index: 18
view all 9 authors...
BACKGROUND AND PURPOSE: Type 2 diabetes is one of the most severe chronic diseases and is becoming an increasingly serious public health trouble worldwide. There are several glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed to treat the type 2 diabetes. However, most of them are injectable form, which immensely reduce the tolerance of patients and increase the risk of infection. Here, we designed a novel orally available GLP-1RA with only replacing the amino acids in exendin-4,...
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#1Hong Tian (CPU: China Pharmaceutical University)H-Index: 9
#2Yanliang Kang (CPU: China Pharmaceutical University)
Last. Xiangdong Gao (CPU: China Pharmaceutical University)H-Index: 20
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Abstract Despite the clinical success of immune checkpoint blockade, only a subset of people exhibits durable responses, suggesting that an alternative immunotherapeutic strategy is required. This paper reported a two-in-one cancer vaccine that targets programmed death ligand 1 (PDL1) that blocks the PD1/PDL1 pathway and also activates antitumor immune response. The PDL1– NitraTh vaccine, which consists of the extracellular domain of PDL1 and nitrated T cell epitope, effectively broke the immune...
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#1Xiaoda Song (CPU: China Pharmaceutical University)H-Index: 1
#2Yuting Yi (CPU: China Pharmaceutical University)H-Index: 1
Last. Xiangdong Gao (CPU: China Pharmaceutical University)H-Index: 20
view all 8 authors...
Abstract Monellin, one kind of most sweet proteins, could be used instead of carbohydrates in the diabetic diet and pharmaceuticals. However, the critical problem interferes with monellin usage in the food or pharmaceutical industry was its unstable at high temperatures. Here, we describe a novel method to increase the thermostability of monellin. Inspired by the high T m value in RNA hairpin containing structure, the beta-hairpin was added between the two polypeptide chains of monellin instead ...
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#1Wei Liu (CPU: China Pharmaceutical University)H-Index: 15
#2Shuai Tang (CPU: China Pharmaceutical University)H-Index: 1
Last. Xiangdong Gao (CPU: China Pharmaceutical University)H-Index: 20
view all 7 authors...
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology with increasing incidence world widely. Previous studies have indicated that the α-D-glucan YCP purified from the mycelium of the marine fungus Phoma herbarum YS4108 had certain immunomodulatory activities in animal and cell models. In the study, the therapeutic effect and intestinal regulatory activity of YCP (40 mg/kg, intraperitoneal injection) on UC were investigated in dextran sulfate sodium (DSS)-i...
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Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because of the crucial role of the IL-23/IL-17 axis in the pathogenesis of psoriasis, and it has recently been reported to be involved in ILC3 cell differentiation. In this study, we report that eukaryotically expressed rhIL23R-CHR/Fc, as an endogenous extracellular receptor analogue, could be a natural antagonist in an imiquimod (IMQ)-induced psoriasis-like mouse model, including the antagonizing ef...
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#1Xiaoda Song (CPU: China Pharmaceutical University)H-Index: 1
#2Xiaofei Chen (CPU: China Pharmaceutical University)H-Index: 3
Last. Wenbing Yao (CPU: China Pharmaceutical University)H-Index: 18
view all 7 authors...
Abstract Designed ankyrin repeat proteins (DARPins) are a kind of proteins containing the similar characteristics to antibodies. Which can specifically bind the target with high affinity. Here, we described an efficient method to select of DARPins effectively against the programmed death-ligand 1(PD-L1), a prominent target for cancer immune therapy, by E. coli surface display. E. coli surface display combined with magnetic cell sorting (MACS) were easy to manipulate with the advantages of solubi...
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#1Huan Li (CPU: China Pharmaceutical University)H-Index: 1
#2Zichen Wang (CPU: China Pharmaceutical University)H-Index: 1
Last. Wenying Liu (CPU: China Pharmaceutical University)H-Index: 15
view all 6 authors...
Abstract Two proteoglycans (HPP and LPP) with different ratios of protein/polysaccharide were extracted from S. glabra. The chemical compositions, relative average molecular weights, monosaccharide compositions, FT-IR spectra, and rheological properties of the two proteoglycans were determined. The results exhibited that the two proteoglycans had pseudoplastic fluids properties and displayed shear-thinning behavior. The apparent viscosity of the two proteoglycans both increased with increasing c...
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#1Kaidong Li (CPU: China Pharmaceutical University)H-Index: 1
#2Lingling Zhu (CPU: China Pharmaceutical University)H-Index: 1
Last. Wenying Liu (CPU: China Pharmaceutical University)H-Index: 15
view all 7 authors...
Abstract A new pectin (ALP-2) was extracted from the roots of Arctium lappa L. with the molecular weight of 1.84 × 106 Da. ALP-2 was composed of rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, xylose and arabinose. Results of NMR revealed that the dominant linkage types of ALP-2 were →4-α-GalpA-6-OMe-(1→, →2-α-Rha-(1→, →5-α-Araf-(1→ and →3,6-β-Galp-(1→. The ELISA results indicated ALP-2 was a typical pectin with HG chain and RG-I chain. The rheological experiments showed that A...
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