Original paper
Single‐chain factor XII exhibits activity when complexed to polyphosphate
Volume: 12, Issue: 9, Pages: 1513 - 1522
Published: Sep 1, 2014
Abstract
The mechanism underpinning factor XII autoactivation was originally characterized with non-physiological surfaces, such as dextran sulfate (DS), ellagic acid, and kaolin. Several 'natural' anionic activating surfaces, such as platelet polyphosphate (polyP), have now been identified.To analyze the autoactivation of FXII by polyP of a similar length to that found in platelets (polyP70 ).PolyP70 showed similar efficacy to DS in stimulating...
Paper Details
Title
Single‐chain factor XII exhibits activity when complexed to polyphosphate
Published Date
Sep 1, 2014
Volume
12
Issue
9
Pages
1513 - 1522
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Notes
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