Preparation and Antitumor Effect of N-Trimethylchitosan/Fucoidan Ion-Complex Submicron Particles

The aim of this study was to develop a delivery system to enable the promotion of the antitumor potential of fucoidan (FUC). FUC/N-trimethylchitosan (TMC) ion-complex submicron particles (FUC/TMC-SMP) were produced by ionic complexation, and their particle characteristics were investigated. Antitumor effect was examined in vivo using sarcoma 180-bearing mice by oral administration, and body weight loss was checked as an index of toxic side...