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Masanaho Sasatsu
Hoshi University
Organic chemistryChemistryIn vivoMaltitolChromatography
20Publications
10H-index
212Citations
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Publications 20
Newest
#1Kaoru Hirose (TMU: Tokyo Medical University)H-Index: 1
#2Masanaho Sasatsu (Hoshi University)H-Index: 10
Last. Hiraku Onishi (Hoshi University)H-Index: 24
view all 4 authors...
1 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Masashi Nakamura (Hoshi University)H-Index: 1
Last. Masanaho Sasatsu (Hoshi University)H-Index: 10
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1 CitationsSource
#1Satoshi Kitaoka (Hoshi University)H-Index: 2
#2Jo Hatogai (Hoshi University)H-Index: 1
Last. Wataru Ochiai (Hoshi University)H-Index: 12
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Source
#1Yayoi Kawano (Ridai: Tokyo University of Science)H-Index: 2
#2Masanaho Sasatsu (Hoshi University)H-Index: 10
Last. Hiraku Onishi (Hoshi University)H-Index: 24
view all 6 authors...
Stomatitis induced by radiation therapy or cancer chemotherapy is a factor in sleep disorders and/or eating disorders, markedly decreasing patient quality of life. In recent years, disintegrating oral films that are easy to handle have been developed; therefore, we focused on the formulation of these films. We prepared an adhesive film for the oral cavity using xyloglucan (Xylo), which is a water-soluble macromolecule. We used loperamide, which has been reported to relieve pain caused by stomati...
2 CitationsSource
#1Yuri Ikeuchi-Takahashi (Hoshi University)H-Index: 3
#2Masanaho Sasatsu (Hoshi University)H-Index: 10
Last. Hiraku Onishi (Hoshi University)H-Index: 24
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Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered for pain relief from oral mucositis. However, the systemic administration of NSAIDs is limited due to systemic side effects. To avoid these side effects and treat local lesions effectively, a matrix type mucoadhesive tablet was developed. A mixture of hard fat, ethylcellulose (EC) and polyethylene glycol (PEG) was used as a matrix base, and indomethacin (IMC) was used as the principal agent. In tablets consisting of hard fat...
12 CitationsSource
#1Yuri Ikeuchi-Takahashi (Hoshi University)H-Index: 3
#2Naoko Watanabe (Nihon Pharmaceutical University)H-Index: 1
Last. Hiraku Onishi (Hoshi University)H-Index: 24
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Context: Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered for pain relief from oral mucositis. However, the systemic administration of NSAIDs is limited due to the side effects of thrombocytopenia.Objective: To avoid systemic side effects, a matrix type mucoadhesive tablet as a topical application preparation to treat oral aphtha was developed.Methods: A mixture of hard fat with a low irritant property and mucoadhesive polymers was used as the matrix base, and indomethacin was used...
5 CitationsSource
#1Kazuya HayashiH-Index: 1
#2Masanaho SasatsuH-Index: 10
Last. Hiraku OnishiH-Index: 24
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4 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Yuta Saito (Hoshi University)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
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Recently, many people have developed rheumatoid arthritis (RA), and prednisolone (PD) is often used for treatment; however, long use and a large dose of PD can cause toxic side effects. In this study, in order to enhance the therapeutic effects and to suppress the toxic side effects, the conjugate (GC–SP) was prepared by coupling between glycol-chitosan (GC) and succinyl-prednisolone (SP). The drug-release properties of GC–SP were examined and analyzed kinetically. The plasma concentration–time ...
10 CitationsSource
#1Yayoi Kawano (Hoshi University)H-Index: 3
#2Akihiko Ito (Meiji Pharmaceutical University)H-Index: 7
Last. Hiraku Onishi (Hoshi University)H-Index: 14
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Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcrystalline cellulose (AvicelPH-302) and mannitol were added as excipients at a mixing ratio of 1/1 by weig...
9 CitationsSource
#1Yoko Sakuda (Hoshi University)H-Index: 1
#2Akihiko Ito (Meiji Pharmaceutical University)H-Index: 7
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
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Medicinal carbon (MC) films, which can be taken more easily than other dosage forms, were prepared using sodium carboxymethyl cellulose (CMC), hydroxypropylmethyl cellulose (HPMC) and alginic acid sodium (ALG) as film base materials. Brilliant blue FCF (BB) was used as a model drug. The films containing MC had sufficient strength and disintegration time, but their ability to adsorb BB was clearly inhibited compared to that of MC in powder form. When ALG was used as the film base, the BB adsorpti...
12 CitationsSource
12