Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus

Published on Dec 1, 2004in International Journal of Obesity4.51
· DOI :10.1038/sj.ijo.0802853
Leonie K. Heilbronn37
Estimated H-index: 37
(Pennington Biomedical Research Center),
S R Smith10
Estimated H-index: 10
(Pennington Biomedical Research Center),
Eric Ravussin99
Estimated H-index: 99
(Pennington Biomedical Research Center)
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
  • References (140)
  • Citations (298)
Published on Feb 6, 2006in Annals of the New York Academy of Sciences4.29
Bruce A. Boston16
Estimated H-index: 16
(OHSU: Oregon Health & Science University)
: It has been demonstrated that adipocytes express high affinity ACTH and α-MSH binding sites, and that ACTH, α-MSH, and β-LPH are potent lipolytic Hormones. Considerable species variability exists in the lipolytic response to melanocortins, however. Recently, MC2 and MC5 receptor-MRNA was found in both murine adipocytes and in the 3T3-L1 murine embryonic fibroblast cell line, but only after the 3T3-L1 cells had differentiated into adipocytes. The 3T3-L1 cell line was used to characterize the ph...
Published on Jan 25, 2006in Annals of the New York Academy of Sciences4.29
Jeanine Albu42
Estimated H-index: 42
(Mount Sinai St. Luke's and Mount Sinai Roosevelt),
Albert J. Kovera5
Estimated H-index: 5
(Mount Sinai St. Luke's and Mount Sinai Roosevelt),
Julia A. Johnson8
Estimated H-index: 8
(Mount Sinai St. Luke's and Mount Sinai Roosevelt)
: Although independent associations of visceral fat with the insulin resistance syndrome were previously reported in obese women, the importance of truncal subcutaneous fat in this syndrome is controversial. The method by which the various fat depots are measured may be the reason for the underlying controversy. In the past five years, we have used various methods to measure visceral versus subcutaneous fat distribution in Caucasian (C) and African- American (AA) women and have related it to ins...
Published on May 1, 2004in Diabetologia7.11
Anthony E. Civitarese10
Estimated H-index: 10
(Pennington Biomedical Research Center),
Christopher P. Jenkinson35
Estimated H-index: 35
(University of Texas Health Science Center at San Antonio)
+ 8 AuthorsLawrence J. Mandarino54
Estimated H-index: 54
(University of Texas Health Science Center at San Antonio)
Aims/hypothesis The recent discovery of two adiponectin receptors (AdipoR1 and AdipoR2) will improve our understanding of the molecular mechanisms underlying the insulin-sensitising effect of adiponectin. The aim of this study was to determine for the first time whether skeletal muscle AdipoR1 and/or AdipoR2 gene expression levels are associated with insulin resistance.
Published on Nov 28, 2003in Annual Review of Nutrition8.42
Shamina M. Rangwala8
Estimated H-index: 8
Mitchell A. Lazar113
Estimated H-index: 113
▪ Abstract The major transcriptional factors involved in the adipogenic process include proteins belonging to the CCAAT/enhancer binding protein family, peroxisome proliferator-activated receptor γ, and adipocyte determination and differentiation dependent factor 1, also known as sterol regulatory element-binding protein 1. This process has been characterized with the aid of cell lines that represent various stages in the path of adipocyte commitment, ranging from pluripotent mesodermal fibrobla...
Published on Sep 1, 2003in Diabetes7.20
Bret H. Goodpaster80
Estimated H-index: 80
Andreas Katsiaras4
Estimated H-index: 4
David E. Kelley79
Estimated H-index: 79
Skeletal muscle insulin resistance entails dysregulation of both glucose and fatty acid metabolism. This study examined whether a combined intervention of physical activity and weight loss influences fasting rates of fat oxidation and insulin-stimulated glucose disposal. Obese (BMI >30 kg/m2) volunteers (9 men and 16 women) without diabetes, aged 39 ± 4 years, completed 16 weeks of moderate-intensity physical activity combined with caloric reduction. Body composition was determined by dual-energ...
Published on Aug 1, 2003in Diabetes7.20
Jørn Wulff Helge39
Estimated H-index: 39
Flemming Dela46
Estimated H-index: 46
We studied whether endurance training impacts insulin sensitivity by affecting the structural and storage lipids in humans. Eight male subjects participated (age 25 ± 1 years, height 178 ± 3 cm, weight 76 ± 4 kg [mean ± SE]). Single-leg training was performed for 30 min/day for 4 weeks at ∼70% of single-leg maximal oxygen uptake. After 8, 14, and 30 days, a two-step hyperinsulinemic-euglycemic glucose clamp, combined with catheterization of an artery and both femoral veins, was performed. In add...
Mary-Elizabeth Patti51
Estimated H-index: 51
(Harvard University),
Atul J. Butte69
Estimated H-index: 69
(Harvard University)
+ 14 AuthorsRobert Saccone3
Estimated H-index: 3
(Harvard University)
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. To identify genes potentiall...
Published on Jul 1, 2003in Nature Genetics25.45
Vamsi K. Mootha68
Estimated H-index: 68
(Brigham and Women's Hospital),
Cecilia M. Lindgren82
Estimated H-index: 82
(MIT: Massachusetts Institute of Technology)
+ 18 AuthorsEsa Laurila9
Estimated H-index: 9
(Lund University)
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decrease...
Published on Jul 1, 2003in Diabetes, Obesity and Metabolism6.13
Paul D. Hockings6
Estimated H-index: 6
(GSK: GlaxoSmithKline),
K. Kumar Changani14
Estimated H-index: 14
(GSK: GlaxoSmithKline)
+ 6 AuthorsR. E. Buckingham2
Estimated H-index: 2
(GSK: GlaxoSmithKline)
Aim: This study aimed to chart the time course and durability of the effects of rosiglitazone, a potent thiazolidinedione-based peroxisome proliferator-activated receptor γ agonist, on hepatic steatosis and intramyocellular lipid in an animal model of obesity, the Zucker Fatty (ZF) rat. Methods and Results: Rosiglitazone (3 mg/kg/day p.o.) significantly reduced both liver fat content (by 59%; p < 0.05) and size (11.5%; p < 0.05) in male ZF rats that received between 3 days and 1 week of treatmen...
Published on Jul 1, 2003in Diabetes Care15.27
Claus Thamer36
Estimated H-index: 36
Michael Stumvoll85
Estimated H-index: 85
+ 9 AuthorsAnnette Volk14
Estimated H-index: 14
OBJECTIVE —Studies on insulin sensitivity and insulin secretion in subjects with a familial predisposition for type 2 diabetes mellitus (T2DM) traditionally produce inconsistent results. This may be due to small sample size, subject selection, matching procedures, and perhaps lack of a measure of physical fitness. RESEARCH DESIGN AND METHODS —In the present study, we specifically tested the hypothesis that a family history of T2DM is associated with reduced V o 2max , measured by incremental bic...
Cited By298
Published on Dec 1, 2019in Scientific Reports4.01
Hyo Jung Lee9
Estimated H-index: 9
(CBNU: Chungbuk National University),
Han Byul Jang9
Estimated H-index: 9
+ 4 AuthorsHye Ja Lee4
Estimated H-index: 4
Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes. Increased adipose energy storage in obesity promote insulin resistance and other metabolic adverse effects. To identify a new link between adipocyte and insulin resistance, we performed targeted metabolite profiling of differentiated adipocytes and studied the association between adipogenic metabolites and insulin resistance. We found a correlation between 2-aminoadipic acid (2-...
Published on Feb 18, 2019in Nutrition & Diabetes3.10
S. Wijetunge1
Estimated H-index: 1
(University of Peradeniya),
R. M. C. J. Ratnayake (University of Peradeniya)+ 5 AuthorsNaima Moustaid-Moussa (University of Peradeniya)
Mechanisms of obesity-associated insulin resistance and dysglycemia in South Asians remain relatively unknown. The objective of this study was to detect subcutaneous (SAT) vs. visceral (VAT) adipose tissue characteristics and adipocytokines associated with obesity, insulin resistance, and dysglycemia in South Asian women. This was a hospital-based cross-sectional study conducted in Sri Lanka. Subjects comprised of 58 adult women who underwent routine abdominal surgeries. SAT and VAT were obtaine...
Published on 2019in Scientific Reports4.01
Klev Diamanti4
Estimated H-index: 4
(Science for Life Laboratory),
Marco Cavalli (Science for Life Laboratory)+ 7 AuthorsJan Komorowski33
Estimated H-index: 33
(PAN: Polish Academy of Sciences)
Type 2 diabetes (T2D) mellitus is a complex metabolic disease commonly caused by insulin resistance in several tissues. We performed a matched two-dimensional metabolic screening in tissue samples from 43 multi-organ donors. The intra-individual analysis was assessed across five key metabolic tissues (serum, visceral adipose tissue, liver, pancreatic islets and skeletal muscle), and the inter-individual across three different groups reflecting T2D progression. We identified 92 metabolites differ...
Published on 2019in Cells
Leonardo Sandrini3
Estimated H-index: 3
Alessandro Ieraci12
Estimated H-index: 12
+ 5 AuthorsSilvia S. Barbieri16
Estimated H-index: 16
Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutations as well as common genetic variants, including the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, are associated with increased body weight, eating and neuropsychi...
Kirsten Maria Jansen , Sonia Moreno (University of Barcelona)+ 1 AuthorsTerje S. Larsen28
Estimated H-index: 28
The aim of this study was to find out if dietary supplementation with Calanus oil (a novel marine oil) or infusion of exenatide (an incretin mimetic) can counteract obesity-induced alterations in m...
Published on Apr 1, 2019in Heliyon
Timilehin David Oluwajuyitan , Oluwole Steve Ijarotimi5
Estimated H-index: 5
(FUTA: Federal University of Technology Akure),
Oluwole Steve Ijarotimi
Abstract The study aimed at determining nutritional, antioxidant and blood glucose lowering potentials of improved plantain-based dough meals enriched with defatted soybean and tigernut flour. The constituted dough meals [PSB (plantain 64.46, defatted soybean 35.54%), TNS (tigernut 59.83, defatted soybean 40.17%); PTS (plantain 51.07, tigernut, 11.50, defatted soybean, 37.43%); TNT (100% tigernuts); PLT (100% plantain) and CNT (a commercial flour)] were evaluated for nutritional, antioxidant and...
Manno C22
Estimated H-index: 22
(University of Bari),
Nicla Campobasso4
Estimated H-index: 4
(University of Bari)
+ 5 AuthorsGiovanni De Pergola22
Estimated H-index: 22
(University of Bari)
Background The accumulation of visceral body fat, has been shown to be associated with higher risk of metabolic and cardiovascular disease. This study was addressed to examine whether para- and perirenal fat thickness and epicardial fat thickness were correlated with anthropometric- and cardiometabolic risk factors.
Carolina Nylén5
Estimated H-index: 5
(KI: Karolinska Institutet),
Leonidas S. Lundell4
Estimated H-index: 4
(KI: Karolinska Institutet)
+ 2 AuthorsErik Näslund48
Estimated H-index: 48
(KI: Karolinska Institutet)
Diet intervention in obese adults is the first strategy to induce weight loss and improve insulin sensitivity. We hypothesized that improvements in insulin sensitivity after weight loss from a shor...
Published on Jan 1, 2019
Cilius Esmann Fonvig8
Estimated H-index: 8
(UCPH: University of Copenhagen),
Jens-Christian Holm20
Estimated H-index: 20
(UCPH: University of Copenhagen)
Childhood and adolescent overweight and obesity are prevalent worldwide, and related co-morbidity may be extensive already from early childhood. Children and adolescents with obesity will most likely carry obesity into their adult life with an increased risk of adult obesity-related diseases, death from cardiovascular disease, cancers, and all causes.
Published on Jan 1, 2019
The aim of this chapter is to show how immune cells participate during type 2 diabetes (T2D) establishment. Obesity is a major T2D driver, and it is also associated with insulin resistance (IR). These pathologies appear along with chronic inflammation characterized by an increased expression of proinflammatory molecules such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, resistin, and leptin, whereas anti-inflammatory cytokines as adiponectin, IL-4, IL-10, and IL-1Ra are decr...
View next paperEnlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance.