Match!

Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus

Published on Dec 1, 2004in International Journal of Obesity4.514
· DOI :10.1038/sj.ijo.0802853
Leonie K. Heilbronn37
Estimated H-index: 37
(Pennington Biomedical Research Center),
S R Smith6
Estimated H-index: 6
(Pennington Biomedical Research Center),
Eric Ravussin101
Estimated H-index: 101
(Pennington Biomedical Research Center)
Abstract
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
  • References (140)
  • Citations (305)
📖 Papers frequently viewed together
6,270 Citations
4,516 Citations
559 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References140
Newest
#1Bruce A. Boston (OHSU: Oregon Health & Science University)H-Index: 16
: It has been demonstrated that adipocytes express high affinity ACTH and α-MSH binding sites, and that ACTH, α-MSH, and β-LPH are potent lipolytic Hormones. Considerable species variability exists in the lipolytic response to melanocortins, however. Recently, MC2 and MC5 receptor-MRNA was found in both murine adipocytes and in the 3T3-L1 murine embryonic fibroblast cell line, but only after the 3T3-L1 cells had differentiated into adipocytes. The 3T3-L1 cell line was used to characterize the ph...
79 CitationsSource
#1Jeanine B. Albu (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 44
#2Albert J. Kovera (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 5
Last. Julia A. Johnson (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 8
view all 3 authors...
: Although independent associations of visceral fat with the insulin resistance syndrome were previously reported in obese women, the importance of truncal subcutaneous fat in this syndrome is controversial. The method by which the various fat depots are measured may be the reason for the underlying controversy. In the past five years, we have used various methods to measure visceral versus subcutaneous fat distribution in Caucasian (C) and African- American (AA) women and have related it to ins...
59 CitationsSource
#1Anthony E. Civitarese (Pennington Biomedical Research Center)H-Index: 10
#2Christopher P. Jenkinson (University of Texas Health Science Center at San Antonio)H-Index: 37
Last. Eric Ravussin (Pennington Biomedical Research Center)H-Index: 101
view all 11 authors...
Aims/hypothesis The recent discovery of two adiponectin receptors (AdipoR1 and AdipoR2) will improve our understanding of the molecular mechanisms underlying the insulin-sensitising effect of adiponectin. The aim of this study was to determine for the first time whether skeletal muscle AdipoR1 and/or AdipoR2 gene expression levels are associated with insulin resistance.
219 CitationsSource
▪ Abstract The major transcriptional factors involved in the adipogenic process include proteins belonging to the CCAAT/enhancer binding protein family, peroxisome proliferator-activated receptor γ, and adipocyte determination and differentiation dependent factor 1, also known as sterol regulatory element-binding protein 1. This process has been characterized with the aid of cell lines that represent various stages in the path of adipocyte commitment, ranging from pluripotent mesodermal fibrobla...
274 CitationsSource
#1Bret H. GoodpasterH-Index: 81
#2Andreas KatsiarasH-Index: 4
Last. David E. KelleyH-Index: 79
view all 3 authors...
Skeletal muscle insulin resistance entails dysregulation of both glucose and fatty acid metabolism. This study examined whether a combined intervention of physical activity and weight loss influences fasting rates of fat oxidation and insulin-stimulated glucose disposal. Obese (BMI >30 kg/m2) volunteers (9 men and 16 women) without diabetes, aged 39 ± 4 years, completed 16 weeks of moderate-intensity physical activity combined with caloric reduction. Body composition was determined by dual-energ...
309 CitationsSource
We studied whether endurance training impacts insulin sensitivity by affecting the structural and storage lipids in humans. Eight male subjects participated (age 25 ± 1 years, height 178 ± 3 cm, weight 76 ± 4 kg [mean ± SE]). Single-leg training was performed for 30 min/day for 4 weeks at ∼70% of single-leg maximal oxygen uptake. After 8, 14, and 30 days, a two-step hyperinsulinemic-euglycemic glucose clamp, combined with catheterization of an artery and both femoral veins, was performed. In add...
59 CitationsSource
#1Mary-Elizabeth Patti (Harvard University)H-Index: 52
#2Atul J. Butte (Harvard University)H-Index: 70
Last. Lawrence J. Mandarino (University of Texas Health Science Center at San Antonio)H-Index: 55
view all 17 authors...
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. To identify genes potentiall...
1,555 CitationsSource
#1Claus ThamerH-Index: 36
#2Michael StumvollH-Index: 92
Last. Andreas FritscheH-Index: 72
view all 12 authors...
OBJECTIVE —Studies on insulin sensitivity and insulin secretion in subjects with a familial predisposition for type 2 diabetes mellitus (T2DM) traditionally produce inconsistent results. This may be due to small sample size, subject selection, matching procedures, and perhaps lack of a measure of physical fitness. RESEARCH DESIGN AND METHODS —In the present study, we specifically tested the hypothesis that a family history of T2DM is associated with reduced V o 2max , measured by incremental bic...
53 CitationsSource
#1Paul D. Hockings (GSK: GlaxoSmithKline)H-Index: 6
#2Kumar Changani (GSK: GlaxoSmithKline)H-Index: 6
Last. R. E. Buckingham (GSK: GlaxoSmithKline)H-Index: 2
view all 9 authors...
Aim: This study aimed to chart the time course and durability of the effects of rosiglitazone, a potent thiazolidinedione-based peroxisome proliferator-activated receptor γ agonist, on hepatic steatosis and intramyocellular lipid in an animal model of obesity, the Zucker Fatty (ZF) rat. Methods and Results: Rosiglitazone (3 mg/kg/day p.o.) significantly reduced both liver fat content (by 59%; p < 0.05) and size (11.5%; p < 0.05) in male ZF rats that received between 3 days and 1 week of treatmen...
52 CitationsSource
#1Vamsi K. Mootha (MIT: Massachusetts Institute of Technology)H-Index: 70
#2Cecilia M. Lindgren (MIT: Massachusetts Institute of Technology)H-Index: 89
Last. Leif Groop (Lund University)H-Index: 133
view all 21 authors...
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decrease...
4,406 CitationsSource
Cited By305
Newest
#1Agathocles Tsatsoulis (RMIT: RMIT University)H-Index: 1
#1Agathocles Tsatsoulis (RMIT: RMIT University)
Last. Stavroula A. Paschou (UoA: National and Kapodistrian University of Athens)H-Index: 7
view all 2 authors...
PURPOSE OF REVIEW: To present a comprehensive overview regarding criteria, epidemiology, and controversies that have arisen in the literature about the existence and the natural course of the metabolic healthy phenotype. RECENT FINDINGS: The concept of metabolically healthy obesity (MHO) implies that a subgroup of obese individuals may be free of the cardio-metabolic risk factors that commonly accompany obese subjects with adipose tissue dysfunction and insulin resistance, known as having metabo...
Source
#1Philip Maffetone (AUT: Auckland University of Technology)
#2Paul B. Laursen (AUT: Auckland University of Technology)H-Index: 44
The earliest humans relied on large quantities of metabolic energy from the oxidation of fatty acids to develop larger brains and bodies, prevent and reduce disease risk, extend longevity, in addition to other benefits. This was enabled through the consumption of a high fat and low carbohydrate diet. Increased fat oxidation also supported daily bouts of prolonged, low-intensity, aerobic-based physical activity. Over the past 40-plus years, a clinical program has been developed to help people man...
Source
#1Rodolfo Quintana-Castro (Universidad Veracruzana)H-Index: 3
Last. Alfonso Alexander-Aguilera (Universidad Veracruzana)H-Index: 4
view all 9 authors...
Abstract Obesity is considered a global epidemic and is mainly associated with the development of diabetes, cardiovascular diseases and Non-Alcoholic Fatty Liver (NAFLD). The pathogenesis between obesity and hepatic steatosis is partially known, but could involve differentiated or tissue-specific participation of the expression of Cd36 mRNA that codes for a receptor which is a transporter of free fatty acids (FFA) in different tissues, favoring the lipids storage. This relative expression was ev...
Source
#1Sini Heinonen (UH: University of Helsinki)H-Index: 7
#2Riikka Jokinen (UH: University of Helsinki)H-Index: 4
Last. Kirsi H. Pietiläinen (UH: University of Helsinki)H-Index: 49
view all 4 authors...
White adipose tissue is one of the largest organs of the body. It plays a key role in whole-body energy status and metabolism; it not only stores excess energy but also secretes various hormones and metabolites to regulate body energy balance. Healthy adipose tissue capable of expanding is needed for metabolic well-being and to prevent accumulation of triglycerides to other organs. Mitochondria govern several important functions in the adipose tissue. We review the derangements of mitochondrial ...
3 CitationsSource
Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from the subcutaneous adipose tissue depot (SAT). However, the changes in this depot and functions and as well as its relative contribution to the beneficial effects of this surgery are still controversial. With the aim of studying altered proteins and molecular pathways in abdominal SAT (aSAT)...
Source
#1Tianhua Zhang (CSU: Central South University)
#2Jin Chen (CSU: Central South University)
Last. Bi-Lian Yu (CSU: Central South University)H-Index: 3
view all 6 authors...
Obesity is the most common nutritional disorder worldwide and is associated with dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in obesity is low high density lipoprotein (HDL) cholesterol (HDL-C) levels. Moreover, the quality of HDL is also changed in the obese setting. However, there are still some disputes on the explanations for this phenomenon. There is increasing evidence that adipose tissue, as an energy storage tissue, participates in several metabo...
Source
#1Qin Hu (CQMU: Chongqing Medical University)H-Index: 1
#2Yu Mao (CQMU: Chongqing Medical University)H-Index: 1
Last. Feng-Jin Guo (CQMU: Chongqing Medical University)H-Index: 8
view all 6 authors...
1 CitationsSource
This paper reviews our present knowledge on the contribution of ceramide (Cer), sphingomyelin (SM), dihydroceramide (DhCer) and sphingosine-1-phosphate (S1P) in obesity and related co-morbidities. Specifically, in this paper, we address the role of acyl chain composition in bodily fluids for monitoring obesity in males and females, in aging persons and in situations of environmental hypoxia adaptation. After a brief introduction on sphingolipid synthesis and compartmentalization, the node of det...
Source
#1Hyo Jung Lee (CBNU: Chungbuk National University)H-Index: 10
#2Han Byul JangH-Index: 9
Last. Hye Ja LeeH-Index: 4
view all 7 authors...
Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes. Increased adipose energy storage in obesity promote insulin resistance and other metabolic adverse effects. To identify a new link between adipocyte and insulin resistance, we performed targeted metabolite profiling of differentiated adipocytes and studied the association between adipogenic metabolites and insulin resistance. We found a correlation between 2-aminoadipic acid (2-...
Source
#1Leonardo SandriniH-Index: 4
#2Alessandro IeraciH-Index: 12
Last. Silvia S. BarbieriH-Index: 16
view all 8 authors...
Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutations as well as common genetic variants, including the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, are associated with increased body weight, eating and neuropsychi...
1 CitationsSource