Leonie K. Heilbronn
University of Adelaide
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
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Publications 138
#1Xiao Tong Teong (University of Adelaide)H-Index: 1
Last. Leonie K. HeilbronnH-Index: 37
view all 9 authors...
Abstract Background Intermittent fasting (IF) is proposed as a viable alternative to moderate calorie restriction (CR) for weight loss and metabolic health, but few long term randomized trials have been conducted. This protocol paper describes the rationale and detailed protocol for DIRECT study ( D aily versus I ntermittent R estriction of E nergy: C ontrolled T rial to Reduce Diabetes Risk), comparing long term effectiveness of IF versus CR on metabolic health in individuals who are at increas...
#1Kai Liu (University of Adelaide)
#2Bo Liu (University of Adelaide)H-Index: 5
Last. Leonie K. Heilbronn (University of Adelaide)H-Index: 37
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Abstract Obesity and overweight are contributing factors to chronic disease. Lifestyle management, which incorporates advice on moderate daily caloric restriction (CR) and physical activity to reduce body weight, is the cornerstone treatment in practice. Intermittent fasting (IF) is a popular alternative that cycles fasting with unrestricted eating periods. IF appears to be an equivalent approach to CR to induce weight loss, although as yet there is limited long-term evidence. Some controversy e...
#2Sophie M. DrakeH-Index: 5
Last. Morton G. BurtH-Index: 15
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OBJECTIVES: To determine whether relative hyperglycemia was associated with in-hospital mortality in critically ill patients independent of other prognostic variables and whether this association is affected by background glycemia. DESIGN: Prospective observational study. SETTING: Mixed medical-surgical ICU in a metropolitan teaching hospital. PATIENTS: From 2,617 admissions to ICU between January 27, 2016, and March 30, 2017, 1,262 consecutive patients who met inclusion and exclusion criteria w...
This Perspective for Progress provides a synopsis for the potential of time-restricted eating (TRE) to rescue some of the deleterious effects on circadian biology induced by our modern-day lifestyle. We provide novel insights into the comparative and potential complementary effects of TRE and exerci
1 CitationsSource
#1Prabin Gyawali (University of Adelaide)H-Index: 7
#2Sean A. Martin (University of Adelaide)H-Index: 17
Last. Gary A. Wittert (University of Adelaide)H-Index: 55
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2 CitationsSource
#1Charlotte C. Gupta (UniSA: University of South Australia)H-Index: 3
#2Stephanie Centofanti (UniSA: University of South Australia)H-Index: 5
Last. Siobhan Banks (UniSA: University of South Australia)H-Index: 23
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ABSTRACTAltering meal timing could improve cognition, alertness, and thus safety during the nightshift. This study investigated the differential impact of consuming a meal, snack, or not eating dur...
#1Bo Liu (University of Adelaide)H-Index: 5
#2Amanda J. Page (University of Adelaide)H-Index: 39
Last. Leonie K. Heilbronn (University of Adelaide)H-Index: 37
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Abstract Objective Intermittent fasting (IF) may limit metabolic adaptations that reduce energy expenditure, potentially by stimulating white adipose tissue (WAT) browning. The aim of this study was to examine the effects of 8 wk of IF on energy metabolism and markers of WAT browning in lean and diet-induced obese mice and in women who were overweight or obese. Methods Male C57 BL/6 J mice were fed chow or a high-fat diet (HFD; 43%) for 8 wk before undergoing IF (3 non-consecutive d/wk) for an a...
#1Leonie K. Heilbronn (University of Adelaide)H-Index: 37
#2Satchidananda Panda (Salk Institute for Biological Studies)H-Index: 51
Various forms of fasting improve health and longevity in preclinical models. However, safety, outcomes, and the molecular changes underpinning human fasting are unclear. Stekovic et al. (2019) report improved markers of health for up to 6 months and associated metabolic changes among healthy adults who followed alternate-day fasting.
#1Dylan J. HarneyH-Index: 3
#2Amy T. HutchisonH-Index: 8
Last. Mark LaranceH-Index: 18
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1 CitationsSource
#1Miaoxin Chen (University of Adelaide)H-Index: 6
#2Siew L. Wong (University of Adelaide)H-Index: 2
Last. Rebecca L. Robker (University of Adelaide)H-Index: 38
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ABSTRACT Research question Conception via assisted reproduction technology (ART) increases the risk of type 2 diabetes and cardiovascular disease in adulthood. Underlying differences between ART-conceived and in-vivo-conceived embryos that contribute to this increased risk are, however, not known. Design This study examined the developmental characteristics of mouse blastocysts derived from ART- compared with in-vivo-conceived embryos. To determine the effect of ovarian stimulation versus IVF ve...