Leonie K. Heilbronn
University of Adelaide
Publications 134
#1Bo LiuH-Index: 3
#2Amanda J. PageH-Index: 36
Last.Leonie K. HeilbronnH-Index: 37
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Abstract Objective Intermittent fasting (IF) may limit metabolic adaptations that reduce energy expenditure, potentially by stimulating white adipose tissue (WAT) browning. The aim of this study was to examine the effects of 8 wk of IF on energy metabolism and markers of WAT browning in lean and diet-induced obese mice and in women who were overweight or obese. Methods Male C57 BL/6 J mice were fed chow or a high-fat diet (HFD; 43%) for 8 wk before undergoing IF (3 non-consecutive d/wk) for an a...
#1Leonie K. Heilbronn (University of Adelaide)H-Index: 37
#2Satchidananda Panda (Salk Institute for Biological Studies)H-Index: 49
Various forms of fasting improve health and longevity in preclinical models. However, safety, outcomes, and the molecular changes underpinning human fasting are unclear. Stekovic et al. (2019) report improved markers of health for up to 6 months and associated metabolic changes among healthy adults who followed alternate-day fasting.
#1Miaoxin Chen (University of Adelaide)H-Index: 6
#2Siew L. Wong (University of Adelaide)H-Index: 2
Last.Rebecca L. Robker (University of Adelaide)H-Index: 38
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ABSTRACT Research question Conception via assisted reproduction technology (ART) increases the risk of type 2 diabetes and cardiovascular disease in adulthood. Underlying differences between ART-conceived and in-vivo-conceived embryos that contribute to this increased risk are, however, not known. Design This study examined the developmental characteristics of mouse blastocysts derived from ART- compared with in-vivo-conceived embryos. To determine the effect of ovarian stimulation versus IVF ve...
#1Bo Liu (University of Adelaide)H-Index: 3
#2Amy T. Hutchison (University of Adelaide)H-Index: 7
Last.Leonie K. Heilbronn (University of Adelaide)H-Index: 37
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Abstract Objective This study compared the effects of daily calorie restriction (DR) versus intermittent fasting (IF) on markers of inflammation and extracellular matrix deposition in adipose tissue and skeletal muscle in a controlled feeding trial in women with overweight or obesity. Methods Women (N = 76) were randomised to one of three diets and provided with all foods at 100% (IF100) or 70% (IF70 and DR70) of calculated energy requirements for 8 weeks. IF groups ate breakfast prior to fastin...
#1Charlotte GuptaH-Index: 3
Last.Manny NoakesH-Index: 62
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Shiftworkers report eating during the night when the body is primed to sleep. This study investigated the impact of altering food timing on subjective responses. Healthy participants (n = 44, 26 male, age Mean ± SD = 25.0 ± 2.9 years, BMI = 23.82 ± 2.59kg/m2) participated in a 7-day simulated shiftwork protocol. Participants were randomly allocated to one of three eating conditions. At 00:30, participants consumed a meal comprising 30% of 24 h energy intake (Meal condition; n = 14, 8 males), a s...
#1Alice TangH-Index: 1
#2Adelle C. F. CosterH-Index: 17
Last.Aimin XuH-Index: 68
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Background: Large cohort longitudinal studies have almost unanimously concluded that metabolic health in obesity is a transient phenomenon, diminishing in older age. We aimed to assess the fate of insulin sensitivity per se over time in overweight and obese individuals. Methods: Individuals studied using the hyperinsulinaemic-euglycaemic clamp at the Garvan Institute of Medical Research from 2008 to 2010 (n = 99) were retrospectively grouped into Lean (body mass index (BMI) < 25 kg/m2) or overwe...
#1Dylan J. Harney (USYD: University of Sydney)H-Index: 2
#2Amy T. Hutchison (University of Adelaide)H-Index: 7
Last.Mark Larance (USYD: University of Sydney)H-Index: 17
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Intermittent fasting (IF) increases lifespan and decreases metabolic disease phenotypes and cancer risk in model organisms, but the health benefits of IF in humans are less clear. Human plasma derived from clinical trials is one of the most difficult sample sets to analyze using mass spectrometry-based proteomics due to the extensive sample preparation required and the need to process many samples to achieve statistical significance. Here, we describe an optimized and accessible device (Spin96) ...