High-throughput functional genomics using CRISPR–Cas9
Abstract
CRISPR–Cas9 has been adopted as a powerful genome-editing technology in various species. By generating libraries of thousands of guide RNAs — which direct the Cas9 nuclease to chosen genomic loci — high-throughput genetic perturbations are now possible. This Review discusses the latest applications of CRISPR–Cas9 in mammalian functional genomics screens. It covers related genome-scale applications of Cas9 for either gene knockout or...
Paper Details
Title
High-throughput functional genomics using CRISPR–Cas9
Published Date
Apr 9, 2015
Journal
Volume
16
Issue
5
Pages
299 - 311
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Notes
History