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Nature Reviews Genetics
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Two papers in Nature Chemical Biology describe new methods for transcriptome-mapping of N6-methyladenosine (m6A), a covalent modification of RNA. In m6A-SEAL, modified adenosines can be tagged with different functional groups for different applications, whereas m6A-label-seq uses metabolic labelling to achieve single-nucleotide resolution.
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#1Anna Orteu (University of Cambridge)H-Index: 1
#2Chris D. Jiggins (University of Cambridge)H-Index: 1
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#1Paschalia Kapli (UCL: University College London)H-Index: 12
#2Ziheng Yang (UCL: University College London)H-Index: 85
Last. Maximilian J. Telford (UCL: University College London)H-Index: 35
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Knowing phylogenetic relationships among species is fundamental for many studies in biology. An accurate phylogenetic tree underpins our understanding of the major transitions in evolution, such as the emergence of new body plans or metabolism, and is key to inferring the origin of new genes, detecting molecular adaptation, understanding morphological character evolution and reconstructing demographic changes in recently diverged species. Although data are ever more plentiful and powerful analys...
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A study reports on the suitability of the yeast Saccharomyces cerevisiae as a platform for the assembly and maintenance of diverse RNA virus genomes, including SARS-CoV-2.
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#1Anna Orteu (University of Cambridge)H-Index: 1
#2Chris D. Jiggins (University of Cambridge)H-Index: 1
Coloration is an easily quantifiable visual trait that has proven to be a highly tractable system for genetic analysis and for studying adaptive evolution. The application of genomic approaches to evolutionary studies of coloration is providing new insight into the genetic architectures underlying colour traits, including the importance of large-effect mutations and supergenes, the role of development in shaping genetic variation and the origins of adaptive variation, which often involves adapti...
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A study in Cell describes a novel, highly scalable CRISPR–Cas9-based assay and its use in assessing the role of enhancer mutations in mammalian limb development.
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RNA interference screening in Caenorhabditis elegans has identified two repressive epigenetic regulators of age-related behavioural performance that are conserved in mammals.
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A new technology, named PIC-seq, combines cell sorting of physically interacting cells (PICs) with single-cell RNA sequencing and computational modelling to profile cellular interactions and their impact on gene expression.
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Two new studies in Nature Biotechnology demonstrate the feasibility of functional genomics systems beyond Cas9: a combinatorial DNA editing system involving both Cas9 and Cas12a, and an RNA-targeted system based on Cas13.
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Two studies in Molecular Cell report fine-scale structural profiles of mammalian genomes using Micro-C, indicating that fine chromosomal structure is regulated by diverse transcription-related features.
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