De novo mutations in schizophrenia implicate synaptic networks
Abstract
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de novo) mutations, in the form of large chromosomal copy number changes, occur in a small fraction of cases and disproportionally disrupt genes encoding postsynaptic proteins. Here we show that small de novo mutations, affecting one or a few nucleotides, are overrepresented among glutamatergic postsynaptic proteins comprising activity-regulated...
Paper Details
Title
De novo mutations in schizophrenia implicate synaptic networks
Published Date
Jan 22, 2014
Journal
Volume
506
Issue
7487
Pages
179 - 184
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