Functional Analysis of Mutations in the TRESK K2P Potassium Channel Associated with ‘migraine with Aura’

An inherited mutation in the KCNK18 gene has been shown to be associated with ‘migraine with aura’. This is a common, debilitating, recurrent headache disorder associated with transient and reversible focal neurological symptoms. KNCK18 encodes the TWIK-related spinal cord potassium channel (TRESK), a member of the K2P family of potassium channels. The F139WfsX24 mutation, segregates perfectly with typical migraine with aura in a large pedigree...