Control of Prostate Cancer Using Organotin Polymers
Published on May 1, 2015in Journal of Inorganic and Organometallic Polymers and Materials 1.64
· DOI :10.1007/s10904-014-0048-6
The current efforts described in this paper are aimed at developing compounds that inhibit the growth of prostate cancer and to identify structure/property relationships that will further assist us towards this goal. The growth of prostate cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependant on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the picogram/mL range are found. A number of products exhibit CI50 values greater than two. For polymers derived from hydroquinone and hydroquinone derivatives ability to inhibit cancer cell growth decreases as the bulk of substituents increases.