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Clinical utility of 18F-DOPA-PET in movement disorders. A systematic review

Published on May 1, 2009in Revista Espanola De Medicina Nuclear0.93
· DOI :10.1016/S1578-200X(09)70018-X
Jeannette Puñal-Riobóo4
Estimated H-index: 4
,
A. Serena-Puig2
Estimated H-index: 2
+ 2 AuthorsAlberto Ruano-Ravina23
Estimated H-index: 23
(Ciber)
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Abstract
Abstract Introduction 18 F-fluorodopa ( 18 F-DOPA) is a functional tracer of presynaptic dopaminergic neuron terminations in the nigrostriatal system. This review is aimed to assess the efficacy of 18 F-DOPA-PET in the diagnosis and evaluation of the progression of Parkinson's Disease (PD) and in the differential diagnosis with other Parkinsonism Syndromes. Methods A review was made of the literature by searching six databases and selecting the most relevant articles according to strict inclusion and exclusion criteria. The study data were systematically extracted and included in evidence tables. Results Of the 1478 registries recovered through the search of the literature, 48 studies were extracted. Of these, only 13 were included in the systematic review. It was observed in all of them that PD is manifested by a lower striatal uptake of 18 F-DOPA, especially in the putamen with posterior predominance. Prospective studies have shown that there is loss of uptake with disease progression. One article described regional differences in 18 F-DOPA striatal pattern between PD, multisystem atrophy (MSA) and progressive supranuclear palsy (PSP). Cognitive impairment in PD seems to be related with 18 F-DOPA abnormal uptake in some regions of frontal cortex and caudate nucleus. Conclusion 18 F-DOPA-PET seems to be useful for the diagnosis and evaluation of PD progression. However, the evidence is not conclusive regarding its utility in the differential diagnosis with other Parkinsonism Syndromes and in the differentiation between ex novo and advanced PD.
  • References (38)
  • Citations (4)
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References38
Newest
Published on Jul 1, 2008in Psychiatry Research-neuroimaging2.21
Vanessa Cropley19
Estimated H-index: 19
(Swinburne University of Technology),
Masahiro Fujita40
Estimated H-index: 40
+ 8 AuthorsPradeep J. Nathan51
Estimated H-index: 51
(Monash University, Clayton campus)
Abstract Frontostriatal cognitive dysfunction is common in Parkinson disease (PD), but the explanation for its heterogeneous expressions remains unclear. This study examined the dopamine system within the frontostriatal circuitry with positron emission tomography (PET) to investigate pre- and post-synaptic dopamine function in relation to the executive processes in PD. Fifteen non-demented PD patients and 14 healthy controls underwent [ 18 F]FDOPA (for dopamine synthesis) and [ 11 C]NNC 112 (for...
Published on Apr 1, 2008in Revista Espanola De Medicina Nuclear0.93
Maria Collantes6
Estimated H-index: 6
(CIMA: Chartered Institute of Management Accountants),
I. Peñuelas5
Estimated H-index: 5
(CIMA: Chartered Institute of Management Accountants)
+ 10 AuthorsJavier Arbizu24
Estimated H-index: 24
Resumen Objetivo Este trabajo evalua la idoneidad del radiotrazador 11 C-(+)-α-dihidrotetrabenazina ( 11 C-(+)DTBZ) para cuantificar mediante tomografia de emision de positrons (PET) la inervacion dopaminergica en rata y mono, especies utilizadas como modelos animales en el estudio de la enfermedad de Parkinson. Material y metodos En ratas se estudio una poblacion control sana (n = 10) y el efecto del neurotoxico 6-hidroxidopamina (6-OHDA), ademas de realizarse estudios PET con 6-[( 18 )F]-fluor...
Published on Feb 1, 2008in Revista Espanola De Medicina Nuclear0.93
Gemma Quincoces14
Estimated H-index: 14
,
Maria Collantes6
Estimated H-index: 6
+ 11 AuthorsJavier Arbizu24
Estimated H-index: 24
Resumen La dihidrotetrabenazina (2-hidroxi-3-isobutil- 9,10-dimetoxi-1,3,4,6,7-hexahidro-11b H-benzo [a]-quinolizina, DTBZ) se ha convertido en el ligando ideal de los transportadores presinapticos de monoaminas (VMAT2) debido a su elevada afinidad de union y su lipofilicidad. Objetivo Desarrollar un procedimiento de sintesis automatico para el marcaje con carbono-11 de la DTBZ para utilizarla como marcador en el estudio in vivo mediante tomografia por emision de positrones de perdidas neuronale...
Published on Dec 1, 2007in Revista Espanola De Medicina Nuclear0.93
J Puñal Riobóo1
Estimated H-index: 1
(Xunta de Galicia),
L Varela Lema1
Estimated H-index: 1
(Xunta de Galicia)
+ 1 AuthorsAlberto Ruano-Ravina23
Estimated H-index: 23
(University of Santiago de Compostela)
Resumen Introduccion La enfermedad de Parkinson (EP) es la segunda enfermedad degenerativa mas frecuente, afectando al 1-2% de la poblacion mayor de 65 anos. Hasta el 20-24% de los sindromes parkinsonianos pueden ser erroneamente diagnosticados. La finalidad de este trabajo es valorar la eficacia del DaTSCAN © en el reconocimiento de la EP precoz y su diagnostico diferencial del parkinsonismo vascular, el parkinsonismo farmacologico y el temblor esencial, asi como la eficacia del 123I-FP en la d...
Published on Oct 1, 2007in Revista Espanola De Medicina Nuclear0.93
S.J. Ortega Lozano7
Estimated H-index: 7
,
M.D. Martínez del Valle Torres7
Estimated H-index: 7
+ 2 AuthorsV. Campos Arillo4
Estimated H-index: 4
Resumen Objetivo Establecer la validez diagnostica del estudio tomografico con FP-CIT en entidades que cursan con afectacion presinaptica de la via dopaminergica estriato-nigrica y en otras que no lo hacen, valorando la aportacion del analisis cuantitativo. Material y metodos Se incluyen 183 pacientes que tras un periodo de seguimiento se establece desde el punto de vista clinico la existencia o no de parkinsonismo degenerativo y se confronta con el resultado de la tomogammagrafia (SPECT) con FP...
Published on Aug 1, 2006in Revista Espanola De Medicina Nuclear0.93
Montserrat Estorch29
Estimated H-index: 29
(Autonomous University of Barcelona),
Camacho2
Estimated H-index: 2
(Autonomous University of Barcelona)
+ 5 AuthorsIgnasi Carrió38
Estimated H-index: 38
Resumen La demencia con cuerpos de Lewy (DCL) es la segunda causa de demencia degenerativa despues de la enfermedad de Alzheimer (EA), basandose su diagnostico en Criterios Clinicos de Consenso Internacional y siendo el diagnostico de certeza post-mortem . El diagnostico diferencial entre ambas enfermedades permite facilitar el manejo terapeutico de los pacientes con DCL, que presentan una sensibilidad especial a los neurolepticos y un tratamiento dificil de sus sintomas psicoticos. Objetivo Val...
Published on Jan 1, 2006in Health Statistics Quarterly
Clare Griffiths20
Estimated H-index: 20
,
Rooney C8
Estimated H-index: 8
Dementia is the loss of intellectual ability. People with dementia may become confused and unable to remember things or lose skills they once had, including the ability to perform normal daily activities. Eventu-ally, they may not recognise family members or friends and may show agitated behaviour. Although dementia is more common in older adults, it is not a normal consequence of ageing.
Published on Aug 1, 2005in European Neuropsychopharmacology4.47
Sonja von Campenhausen10
Estimated H-index: 10
(LMU: Ludwig Maximilian University of Munich),
Bernhard Bornschein13
Estimated H-index: 13
+ 7 AuthorsRichard Dodel52
Estimated H-index: 52
Objective: To provide an overview on the prevalence and incidence of Parkinson’s disease (PD) in selected European countries. Background: PD is a common disease of unknown etiology. Accurate information on the epidemiology of PD is critical to inform health policy. An aging population will lead to more patients with PD; thus, the high financial burden PD places on society will increase. Material and methods: A systematic literature search was performed to identify studies on the prevalence and i...
Published on Jun 1, 2005in Neurobiology of Aging4.40
Anna Brück13
Estimated H-index: 13
(UTU: University of Turku),
Sargo Aalto32
Estimated H-index: 32
(UTU: University of Turku)
+ 2 AuthorsJuha O. Rinne72
Estimated H-index: 72
(UTU: University of Turku)
Abstract Patients with Parkinson's disease (PD) have already at the early stages of the disease impaired performance especially in tests measuring frontal lobe functions such as attention. The pathophysiological basis of these deficits is unclear. In the present study, 21 non-demented, non-medicated patients at the early stage of PD and 24 healthy controls underwent a positron emission tomography (PET) scan with 6-[ 18 F]fluoro- l -dopa (Fdopa) as the tracer. In addition, the PD patients perform...
Published on Apr 1, 2005in Journal of Neurology, Neurosurgery, and Psychiatry8.27
U Nath1
Estimated H-index: 1
(Newcastle University),
Richard Thomson46
Estimated H-index: 46
(Newcastle University)
+ 4 AuthorsDavid J. Burn80
Estimated H-index: 80
(Newcastle University)
Objective: To estimate the mortality of progressive supranuclear palsy (PSP) and to assess the quality of death certification in patients with PSP who died in England and Wales. Methods: An analysis was conducted of ICD-9 (International Classification of Diseases, version 9) coded deaths obtained through the Office of National Statistics over an eight year period. Results: The crude annual mortality rate was 1.77 (95% confidence interval, 1.64 to 1.90) cases per million, using the mid-1996 popul...
Cited By4
Newest
Published on Jan 1, 2018in NeuroImage: Clinical3.94
Xingfeng Li2
Estimated H-index: 2
(University of Nottingham),
Yue Xing4
Estimated H-index: 4
(University of Nottingham)
+ 2 AuthorsDorothee P. Auer53
Estimated H-index: 53
(University of Nottingham)
Abstract Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alteration. This study aimed to investigate associations between motor subscores and brain GM at voxel...
Published on Jan 1, 2014
Sofia Chatziioannou9
Estimated H-index: 9
(UoA: National and Kapodistrian University of Athens),
Emmanouil Rizos13
Estimated H-index: 13
(UoA: National and Kapodistrian University of Athens)
Imaging of tardive dyskinesia (TD) was for years limited to the anatomical evaluation of the striatum with the use of computed tomography and had eventually moved to the superior anatomical information offered by magnetic resonance imaging. More recently, however, it was demonstrated that functional imaging of dopamine (DA) transporter through the use of single-photon emission computed tomography or of the different steps in DA metabolism through the use of positron emission tomography can shed ...
Published on Sep 1, 2011in Clinical Neurophysiology3.67
Mariano Serrao22
Estimated H-index: 22
(Sapienza University of Rome),
Roberto Di Fabio11
Estimated H-index: 11
(Sapienza University of Rome)
+ 7 AuthorsFrancesco Pierelli36
Estimated H-index: 36
(Sapienza University of Rome)
Abstract Objective Trigemino-cervical reflexes (TCRs) are electromyographic responses induced by electrical stimulation of the trigeminal nerve and recorded in the neck muscles. Trigemino-cervical reflexes are detectable in Parkinson's disease, whereas they are absent in progressive supranuclear palsy (PSP), an atypical parkinsonism associated with brainstem degeneration. To date, no study has investigated TCRs in multiple system atrophy (MSA), another atypical parkinsonism associated with brain...
Chrissa Sioka13
Estimated H-index: 13
(UoI: University of Ioannina),
Andreas Fotopoulos19
Estimated H-index: 19
,
Athanassios P. Kyritsis25
Estimated H-index: 25
(UoI: University of Ioannina)
Parkinson’s disease (PD) consists of loss of pigmented dopamine-secreting neurons in the pars compacta of the midbrain substantia nigra. These neurons project to the striatum (putamen and caudate nucleus) and their loss leads to alterations in the activity of the neural circuits that regulate movement. In a simplified model, two dopamine pathways are involved: the direct pathway, which is mediated through facilitation of the D1 receptors, and the indirect pathway through D2 receptors (inhibitory...