Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis
Abstract
IgG, its subclasses and IgE concentrations were measured in cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients and matched controls as surrogate markers for type 1 and type 2 immunity. IgE indices were significantly reduced in MS patients compared to controls. In contrast, IgG1 was elevated in CSF of MS patients and elevated indices indicated intrathecal synthesis. Because isotype switching to IgE and IgG4 is driven by type...
Paper Details
Title
Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis
Published Date
Dec 1, 2001
Journal
Volume
121
Issue
1-2
Pages
120 - 125
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