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Journal of Neuroimmunology
IF
2.83
Papers
10698
Papers 10673
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Abstract SIRT1 exhibits inhibitory effects on microglial activation-induced neurodegeneration. Regulating SIRT1 may become a novel approach for curing neurodegenerative diseases. Protocatechuic acid (PA), a phenolic acid, has anti-neuroinflammatory effects. The effect of PA on SIRT1 in activated microglia remains unknown. Here, we examined whether PA has anti-inflammatory effects against microglial activation-induced neuronal cell death via regulating SIRT1 in microglia. We found that PA inhibit...
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#1Siqi Liu (JLU: Jilin University)
#2Xuan Zhang (JLU: Jilin University)
Last.Qingyong MengH-Index: 1
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Abstract Neuroinflammation has been considered to be involved in the development of schizophrenia. This study aimed to study circulating autoantibodies for inflammatory cytokines in first-episode schizophrenia. A total of 181 patients and 197 controls were recruited for detection of plasma IgG antibodies against peptide antigens derived from interleukin 1α (IL1α), IL1s, IL6, IL8 and tumour necrosis factor alpha (TNFα). The major finding was that patients with schizophrenia had significantly high...
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#1Michael Heming (WWU: University of Münster)H-Index: 1
#2Lisa Lohmann (WWU: University of Münster)H-Index: 1
Last.Gerd Meyer zu Hörste (WWU: University of Münster)H-Index: 23
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Abstract Distinguishing neurosarcoidosis (NS) from multiple sclerosis (MS) remains challenging and available parameters lack discriminatory power. Comprehensive flow cytometry data of blood and CSF leukocytes of patients with NS (n = 24), MS (n = 49) and idiopathic intracranial hypertension (IIH, n = 52) were analyzed by machine learning algorithms. NS featured a specific immune cell pattern with increased activated CD4+ T cells in CSF and increased plasma cells in blood. Combining blood and CSF...
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#1Tatiane Helena Batista (Universidade Federal de Alfenas)H-Index: 2
#2Ana Cláudia Alves Freire Ribeiro (Universidade Federal de Alfenas)H-Index: 2
Last.Fabiana C. Vilela (Universidade Federal de Alfenas)H-Index: 13
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Abstract Female rats were fed a normal or hypoproteic diet during the phases of gestation and lactation. The male offspring of these rats were grown to adulthood and used to study the effects of maternal protein malnutrition on progeny. The adult male rats were pretreated with either saline or LPS and subjected to behavioral tests 2 and 6 h after administration. Tumor necrosis factor (TNF-α), corticosterone and body temperature were the parameters used for assessment. Two hours after LPS adminis...
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#1Kazumoto Shibuya (Chiba University)H-Index: 21
#2Atsuko Tsuneyama (Chiba University)H-Index: 1
Last.Satoshi Kuwabara (Chiba University)H-Index: 60
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Abstract In demyelinating polyneuropathies, distribution patterns of demyelination reflect underlying pathogenesis. Median and ulnar nerve conduction studies were reviewed in 85 typical chronic inflammatory demyelinating polyneuropathy (CIDP) patients and 29 multifocal acquired demyelinating sensory and motor neuropathy (MADSAM). Distal latencies were prolonged in typical CIDP and near normal in MADSAM. Abnormal amplitude reductions in the nerve trunks were more frequent in MADSAM than typical C...
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#1Tetsuya Akaishi (Tohoku University)H-Index: 10
#2Toshiyuki Takahashi (Tohoku University)H-Index: 32
Last.Ichiro NakashimaH-Index: 38
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Abstract We aimed in this study to elucidate the impact of serum AQP4-IgG titer before starting treatments to the clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD). Serum titer at the onset, measured using live cell-based assay method, did not correlate to the subsequent relapse rate or neurological prognosis. Patients with optic neuritis as the first attack showed significantly higher serum titer than patients with acute myelitis or area postrema syndrome, although the t...
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#1Reinaldo Uribe-San-Martín (UC: Pontifical Catholic University of Chile)H-Index: 3
#2Ethel Ciampi (UC: Pontifical Catholic University of Chile)H-Index: 5
Last.Claudia Cárcamo (UC: Pontifical Catholic University of Chile)H-Index: 5
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Abstract We report the case of a 25-year-old woman who developed temporal lobe epilepsy associated with systemic lupus erythematosus (SLE). Serum and cerebrospinal fluid samples showed high titers of anti-ribosomal P (anti-P) antibodies with negative anti-NMDAR antibodies. She was receiving prednisone and azathioprine, with normalization of SLE serum markers, but without changes in titers of anti-P antibodies. No seizure control was achieved using valproic acid, levetiracetam and lamotrigine. Ho...
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#1Paul Maddison (NUH: Nottingham University Hospitals NHS Trust)H-Index: 26
#2Paul Gozzard (Royal Hallamshire Hospital)
Last.Bethan Lang (John Radcliffe Hospital)H-Index: 51
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Abstract Since approximately 50% of patients with Lambert-Eaton myasthenic syndrome (LEMS) subsequently develop small-cell lung cancer (SCLC), it is important to be able to predict cancer occurrence in these patients at neurological presentation. We aimed to determine whether circulating biomarkers were effective and objective predictors of cancer development in LEMS. We found that the presence of either SOX2, N-type voltage gated calcium channel or GABAb antibodies at LEMS diagnosis was highly ...
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#1D. Pandya (TU: Temple University)
#2V. Hellerslia (TU: Temple University)
Last.E. Gettings (TU: Temple University)
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Abstract Acquired Factor VIII inhibitor is a rare acquired clotting disorder which has been seen in the setting of particular medications, autoimmune disease, and malignancy. Reports of this disorder in patients receiving immunomodulatory therapies for multiple sclerosis are rare. We present a case of a 48 year-old woman with likely development of acquired Factor VIII inhibitor in the setting of interferon beta monotherapy for multiple sclerosis, and discuss the pathogenesis of this disorder whi...
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Abstract Lavandula angustifolia (LaEO) essential oil has been widely used by aromatherapy in the treatment of various clinical conditions, with evidence of its analgesic and anti-inflammatory potential. Our results demonstrate that sixty-five substances were identified in LaEO. Among the compounds found, the major ones were linalool (30.61%) and linalyl acetate (20.36%). We found that LaEO inhalation reduces mechanical hyperalgesia in conditions of chronic inflammatory and neuropathic pain. Furt...
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Top fields of study
Immunology
Multiple sclerosis
Diabetes mellitus
Biology
Immune system