Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

Ischaemia–reperfusion injury (IRI) in the liver is a major complication of transplantation. This Review outlines our current understanding of the cellular and molecular mechanisms that underlie liver IRI and summarizes the latest progress in large animal models and clinical trials of liver IRI. Ischaemia–reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock, resection and transplantation, is a dynamic process that...