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Jerzy W. Kupiec-Weglinski
University of California, Los Angeles
463Publications
57H-index
12.3kCitations
Publications 463
Newest
Published on Aug 1, 2019in Archives of Biochemistry and Biophysics 3.56
Kentaro Kadono (UCLA: University of California, Los Angeles), Kenneth J. Dery (UCLA: University of California, Los Angeles)+ 8 AuthorsRonald W. Busuttil97
Estimated H-index: 97
(UCLA: University of California, Los Angeles)
Abstract Liver transplantation (LT) has become the standard of care for patients with end-stage liver disease and those with hepatic malignancies, while adaptive immune-dominated graft rejection remains a major challenge. Despite potent anti-inflammatory and cytoprotective functions of heme oxygenase-1 (HO-1) overexpression upon innate immune-driven hepatic ischemia reperfusion injury, its role in adaptive immune cell-driven responses remains to be elucidated. We analyzed human biopsies from LT ...
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Published on Jun 1, 2019in Journal of Hepatology 18.95
Yuan Liu (UCLA: University of California, Los Angeles), Tianfei Lu1
Estimated H-index: 1
(UCLA: University of California, Los Angeles)
+ 7 AuthorsHaofeng Ji14
Estimated H-index: 14
(UCLA: University of California, Los Angeles)
Abstract Background & Aims Hepatic ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver resection and transplantation. YAP, the effector of Hippo pathway, is essential in determining cell fate and maintaining homeostasis in the liver. Methods This study systemically evaluated putative role of YAP/Hippo signaling in human orthotopic liver transplantation (OLT) and in a murine model of liver warm IRI. Results Hepatic biopsy specimens from OLT patients (n=60) were c...
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Published on May 7, 2019in Hepatology 14.97
Changyong Li3
Estimated H-index: 3
(WHU: Wuhan University),
Yuting Jin (UCLA: University of California, Los Angeles)+ 7 AuthorsBibo Ke33
Estimated H-index: 33
(UCLA: University of California, Los Angeles)
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Published on Apr 13, 2019in Obesity Surgery 3.60
Emily Whang (UCLA: University of California, Los Angeles), Yuan Liu (UCLA: University of California, Los Angeles)+ 7 AuthorsJerzy W. Kupiec-Weglinski57
Estimated H-index: 57
(UCLA: University of California, Los Angeles)
Objective To determine whether vertical sleeve gastrectomy (VSG) attenuates fibrosis in mice on a high-fat high-cholesterol (HFHC) diet.
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Published on Mar 1, 2019in Current Transplantation Reports
Kojiro Nakamura5
Estimated H-index: 5
(UCLA: University of California, Los Angeles),
Shoichi Kageyama4
Estimated H-index: 4
(UCLA: University of California, Los Angeles),
Jerzy W. Kupiec-Weglinski57
Estimated H-index: 57
(UCLA: University of California, Los Angeles)
Purpose of Review Hepatic ischemia-reperfusion injury (IRI), an inevitable event during liver transplantation, represents a major risk factor for the primary graft dysfunction as well as the development of acute and chronic rejection. Neutrophils, along macrophages, are pivotal in the innate immune-driven liver IRI, whereas the effective neutrophil-targeting therapies remain to be established. In this review, we summarize progress in our appreciation of the neutrophil biology and discuss neutrop...
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Published on Feb 1, 2019in Molecular and Cellular Endocrinology 3.69
Shoichi Kageyama5
Estimated H-index: 5
,
Kojiro Nakamura6
Estimated H-index: 6
,
Jerzy W. Kupiec-Weglinski57
Estimated H-index: 57
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Published on Feb 1, 2019in American Journal of Transplantation 7.16
Shoichi Kageyama4
Estimated H-index: 4
(UCLA: University of California, Los Angeles),
Hirofumi Hirao1
Estimated H-index: 1
(UCLA: University of California, Los Angeles)
+ 11 AuthorsFady M. Kaldas24
Estimated H-index: 24
(UCLA: University of California, Los Angeles)
3 Citations Source Cite
Published on Feb 1, 2019in Transplantation 4.59
Jin Xu , Zhengze Xue + 5 AuthorsHaofeng Ji14
Estimated H-index: 14
Background.Liver ischemia and reperfusion injury (IRI) is a major complication of liver transplant, hepatectomy, and hemorrhagic shock. The cyclin-dependent kinase 2 (CDK2) acts as a pivotal regulator of cell cycle and proliferation.Methods.This study evaluated the modulation and therapeutic potenti
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Published on Nov 1, 2018in Annals of Surgery 9.48
Rebecca A. Sosa7
Estimated H-index: 7
,
Maura Rossetti9
Estimated H-index: 9
+ 7 AuthorsElaine F. Reed49
Estimated H-index: 49
Objective and Background: Pattern recognition receptors (PRRs) on immune and parenchymal cells can detect danger-associated molecular patterns (DAMPs) released from cells damaged during ischemia-reperfusion injury (IRI), in heart attack or stroke settings, but also as an unavoidable consequence of solid organ transplantation. Despite IRI being a significant clinical problem across all solid organ transplants, there are limited therapeutics and patient-specific diagnostics currently available. Me...
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