Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
Abstract
The genome is folded into domains located in compartments that are either transcriptionally inert or transcriptionally permissive. Here we used genome-wide strategies to characterize domains during B cell development. Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription...
Paper Details
Title
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
Published Date
Oct 14, 2012
Journal
Volume
13
Issue
12
Pages
1196 - 1204
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