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Yin C. Lin
Baylor University
Molecular biologyTranscription (biology)Transcription factorBiologyCell biology
28Publications
12H-index
5,873Citations
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Publications 27
Newest
#1Kelsey S. Johnson (Baylor University)H-Index: 1
#2Shaimaa Hussein (Baylor University)
Last. Joe Taube (Baylor University)
view all 8 authors...
Background: Epithelial-mesenchymal transition (EMT) facilitates cellular movements critical for proper development; however, in a carcinoma, EMT promotes metastatic dissemination. Stable intermediate states (partial-EMT) are increasingly implicated in metastatic dissemination while reversal of EMT, termed mesenchymal-epithelial transition (MET), is increasingly implicated in metastatic colonization. To understand the partial and reversible nature of EMT, we characterized chromatin accessibility ...
Source
#1Alexandra Bortnick (UCSD: University of California, San Diego)H-Index: 2
#1Alexandra Bortnick (UCSD: University of California, San Diego)H-Index: 8
Last. Cornelis Murre (UCSD: University of California, San Diego)H-Index: 73
view all 8 authors...
The transition from the follicular B to the plasma cell stage is associated with large-scale changes in cell morphology. Here, we examine whether plasma cell development is also associated with changes in nuclear architecture. We find that the onset of plasma cell development is concomitant with a decline in remote genomic interactions; a gain in euchromatic character at loci encoding for factors that specify plasma cell fate, including Prdm1 and Atf4; and establishment of de novo inter-chromoso...
1 CitationsSource
#1Pawan Noel (TGen: Translational Genomics Research Institute)H-Index: 9
#1Pawan Noel (TGen: Translational Genomics Research Institute)H-Index: 3
Last. Haiyong Han (TGen: Translational Genomics Research Institute)H-Index: 33
view all 6 authors...
Background: Super-enhancers (SEs) are implicated in regulating genes that establish cell identity, state, and fate. Thus, therapeutic targeting of SEs has emerged as a promising approach for cancer treatment. To understand SE-regulation of gene expression in the tumor microenvironment (TME), we mapped the SE landscape in pancreatic ductal adenocarcinoma (PDAC) cell lines and cancer-associated fibroblasts (CAF) derived from different PDAC patients. Given the dismal 5-year survival rate of just 9%...
Source
#1Yi Jin (Scott & White Hospital)H-Index: 3
#2Kenian Chen (Scott & White Hospital)H-Index: 8
Last. Yin C. Lin (Scott & White Hospital)H-Index: 12
view all 14 authors...
Multiple myeloma (MM) is an aggressive cancer that originates from antibody-secreting plasma cells. Although genetically and transcriptionally well characterized, the aberrant gene regulatory networks that underpin this disease remain poorly understood. Here, we mapped regulatory elements, open chromatin, and transcription factor (TF) footprints in primary MM cells. In comparison with normal antibody-secreting cells, MM cells displayed consistent changes in enhancer activity that are connected t...
4 CitationsSource
#1Alexandra Bortnick (UCSD: University of California, San Diego)H-Index: 2
#1Alexandra Bortnick (UCSD: University of California, San Diego)H-Index: 8
Last. Caroline S. Murre (UCSD: University of California, San Diego)H-Index: 3
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Previous studies have indicated that the transcription signature of antibody-secreting cells is closely associated with the induction of the unfolded protein response pathway (UPR). Here we have used genome-wide and single cell analyses to examine the folding patterns of plasma cell genomes. We found that plasma cells adopt a cartwheel configuration and undergo large-scale changes in chromatin folding at genomic regions associated with a plasma cell specific transcription signature. During plasm...
3 CitationsSource
#1Emily Rodela (TGen: Translational Genomics Research Institute)
#2Pawan Noel (TGen: Translational Genomics Research Institute)H-Index: 3
Last. Haiyong Han (TGen: Translational Genomics Research Institute)H-Index: 33
view all 6 authors...
GZ17-6.02 is a synthetic formulation of Arum palaestinum extracts that has shown significant antitumor activity against a variety of cancer types including pancreatic ductal adenocarcinoma (PDAC). Previous studies have showed that GZ17-6.02 significantly inhibited PDAC tumor growth in an orthotopic xenograft mouse model for PDAC. Mechanistically, GZ17-6.02 suppressed the expression of multiple tumor stem cell markers in PDAC cells. However, the exact mechanism of action or cellular targets of GZ...
Source
#1Shaimaa Hussein (Scott & White Hospital)
#2Pawan Noel (TGen: Translational Genomics Research Institute)H-Index: 3
Last. Yin C. Lin (Scott & White Hospital)H-Index: 12
view all 7 authors...
Therapeutic targeting of super-enhancers (SEs) has emerged as a promising approach for cancer treatment. To understand how SEs regulate the gene expression of tumors and their microenvironments, we sought to profile the SE landscape in pancreatic ductal adenocarcinoma (PDAC) cell lines and cancer-associated fibroblast (CAF) cells that were derived from different PDAC patients. The global profiling of the H3K27Ac signals in 6 PDAC and 6 CAF cell lines by chromatin immunoprecipitation coupled to s...
Source
#1Masaki Miyazaki (Kyoto University)H-Index: 15
#2Kazuko Miyazaki (Kyoto University)H-Index: 18
Last. Cornelis Murre (UCSD: University of California, San Diego)H-Index: 73
view all 13 authors...
Summary Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies, we demonstrated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid-tissue-inducer-like cells. E2A...
16 CitationsSource
#1Tae Whan Kim (Baylor University)H-Index: 3
#2Seunghee Hong (Baylor University)H-Index: 8
Last. Yong-Jun Liu (Baylor University)H-Index: 66
view all 8 authors...
Type I IFNs are crucial mediators of human innate and adaptive immunity and are massively produced from plasmacytoid dendritic cells (pDCs). IFN regulatory factor (IRF)7 is a critical regulator of type I IFN production when pathogens are detected by TLR 7/9 in pDC. However, hyperactivation of pDC can cause life-threatening autoimmune diseases. To avoid the deleterious effects of aberrant pDC activation, tight regulation of IRF7 is required. Nonetheless, the detailed mechanisms of how IRF7 transc...
16 CitationsSource
#1Kenian Chen (Baylor University)H-Index: 8
#2Yi Jin (Baylor University)H-Index: 3
Last. Yin C. Lin (Baylor University)H-Index: 12
view all 3 authors...
The RNA-guided CRISPR-Cas9 (clustered, regularly interspaced, short palindromic repeat-CRISPR-associated 9) system has become a revolutionary technology for targeted genome engineering. The critical step of this technology requires the design of a highly specific and efficient guide RNA (gRNA) that will guide the Cas9 nuclease to the complementary DNA target sequence. CRISPR-Explorer is a new and user-friendly web server for selecting optimal CRISPR sites. It implements the latest scoring scheme...
2 CitationsSource
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