Inhibition of Granulocyte cAMP-Phosphodiesterase by Rolipram In Vivo Is Not Sufficient to Protect the Canine Myocardium from Reperfusion Injury

Summary: The purpose of this study was to determine whether the selective type IV cAMP-phosphodiesterase inhibitor rolipram could reduce the reperfusion injury that occurs during myocardial infarction in the anesthetized dog. This question was tested in pentobarbital-anesthetized dogs subject to 90 min of regional myocardial ischemia and 5 h of reperfusion. Dogs were treated with 1 mg/kg of rolipram (i.v., 15 min before reperfusion) followed by...