Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.

Published on Oct 1, 2008in Critical Care Medicine6.971
· DOI :10.1097/CCM.0b013e318186aa49
Trung C. Nguyen15
Estimated H-index: 15
Yong Y. Han16
Estimated H-index: 16
+ 6 AuthorsJoseph A. Carcillo51
Estimated H-index: 51
Background:Thrombocytopenia-associated multiple organ failure (TAMOF) is a poorly understood syndrome in critically ill children. A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS-13), formerly known as von Willebrand factor (VWF) cleaving protease, is decreased in adults with VWF
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