Yong Y. Han
University of Michigan
Intensive care medicineSeptic shockResuscitationSepsisMedicine
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Publications 32
Sepsis is a systemic inflammatory syndrome in response to an infection. With the current resuscitation practice, up to 16% of children with severe sepsis and septic shock still progress to develop multiple organ failure (MOF), a condition that is associated with poor outcome. In this review, we focus on the thrombotic microangiopathic paradigm for the development of sepsis-induced MOF. We describe the clinical observations, emerging experimental and laboratory evidence supporting the concept tha...
#1Yu Kawai (UM: University of Michigan)H-Index: 4
#2Timothy T. CornellH-Index: 20
Last. Gail M. Annich (UM: University of Michigan)H-Index: 22
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Objective To determine the effect of therapeutic plasma exchange (TPE) on hemodynamics, organ failure, and survival in children with multiple organ dysfunction syndrome (MODS) due to sepsis requiring extracorporeal life support (ECLS).
22 CitationsSource
#1Yong Y. HanH-Index: 16
#2Joseph A. CarcilloH-Index: 51
Last. Niranjan KissoonH-Index: 42
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2 CitationsSource
#1David T. Selewski (UM: University of Michigan)H-Index: 22
#2Timothy T. CornellH-Index: 20
Last. Michael HeungH-Index: 23
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Objective In pediatric patients fluid overload (FO) at continuous renal replacement (CRRT) initiation is associated with increased mortality. The aim of this study was to characterize the association between fluid overload at CRRT initiation, fluid removal during CRRT, the kinetics of fluid removal and mortality in a large pediatric population receiving CRRT while on extracorporeal membrane oxygenation (ECMO).
98 CitationsSource
#1Rebecca M. Lombel (UM: University of Michigan)H-Index: 6
#2Mallika Kommareddi (UM: University of Michigan)H-Index: 11
Last. Michael Heung (UM: University of Michigan)H-Index: 23
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Purpose In critically ill pediatric patients, fluid overload (FO) >10% has been identified as a threshold for possible interventions, including initiation of continuous renal replacement therapy (CRRT). However, multiple definitions have been reported, and there remains no consensus method for FO calculation. The goal of this study was to compare different methods of FO determination and to assess their relative value in predicting outcomes.
18 CitationsSource
#1Trung C. NguyenH-Index: 15
#2Hülya BayırH-Index: 48
Last. Shekhar T. VenkataramanH-Index: 22
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ABSTRACT. Objective. In response to the landmark1999 report by the Institute of Medicine and safety initi-atives promoted by the Leapfrog Group, our institutionimplemented a commercially sold computerized physi-cian order entry (CPOE) system in an effort to reducemedical errors and mortality. We sought to test the hy-pothesis that CPOE implementation results in reducedmortality among children who are transported for spe-cialized care. Methods. Demographic, clinical, and mortality datawere collec...
3 Citations
#1Ari R. Joffe (U of A: University of Alberta)H-Index: 33
#2Joe Carcillo (University of Pittsburgh)H-Index: 2
Last. Gonzalo Garcia-Guerra (U of A: University of Alberta)H-Index: 1
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Many believe that the ethical problems of donation after cardiocirculatory death (DCD) have been "worked out" and that it is unclear why DCD should be resisted. In this paper we will argue that DCD donors may not yet be dead, and therefore that organ donation during DCD may violate the dead donor rule. We first present a description of the process of DCD and the standard ethical rationale for the practice. We then present our concerns with DCD, including the following: irreversibility of absent ...
55 CitationsSource
#1David T. Selewski (UM: University of Michigan)H-Index: 22
#2Timothy T. Cornell (UM: University of Michigan)H-Index: 20
Last. Michael Heung (UM: University of Michigan)H-Index: 23
view all 10 authors...
Purpose In pediatric intensive care unit (PICU) patients, fluid overload (FO) at initiation of continuous renal replacement therapy (CRRT) has been reported to be an independent risk factor for mortality. Previous studies have calculated FO based on daily fluid balance during ICU admission, which is labor intensive and error prone. We hypothesized that a weight-based definition of FO at CRRT initiation would correlate with the fluid balance method and prove predictive of outcome.
87 CitationsSource
#1Kathryn Felmet (University of Pittsburgh)H-Index: 7
#2Richard A. Orr (University of Pittsburgh)H-Index: 26
Last. Kimberly R. Roth (University of Pittsburgh)H-Index: 2
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2 CitationsSource
#1Odetola FoH-Index: 1
#2McCollegan JH-Index: 1
Last. Orr RaH-Index: 1
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81 Citations