Joseph A. Carcillo
University of Pittsburgh
Intensive care medicineSeptic shockSepsisAnesthesiaMedicine
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Publications 351
#1Ruchir Gupta (MSU: Michigan State University)
#2Jacob Charron (MSU: Michigan State University)
Last. Jacob Bauss (MSU: Michigan State University)
view all 22 authors...
The SARS-CoV-2 pandemic, starting in 2019, has challenged the speed at which labs perform science, ranging from discoveries of the viral composition to handling health outcomes in humans. The small ~30kb single-stranded RNA genome of Coronaviruses makes them adept at cross species spread and drift, increasing their probability to cause pandemics. However, this small genome also allows for a robust understanding of all proteins coded by the virus. We employed protein modeling, molecular dynamic s...
#1Kathleen L. MeertH-Index: 41
#2Ron ReederH-Index: 10
Last. Mark HallH-Index: 24
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#1Ryan W. Morgan (Children's Hospital of Philadelphia)H-Index: 6
#2Ron Reeder (UofU: University of Utah)H-Index: 10
Last. Christopher J. L. Newth (Children's Hospital Los Angeles)H-Index: 44
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OBJECTIVES: The objective of this study was to compare survival outcomes and intra-arrest arterial blood pressures between children receiving cardiopulmonary resuscitation for bradycardia and poor perfusion and those with pulseless cardiac arrests. DESIGN: Prospective, multicenter observational study. SETTING: PICUs and cardiac ICUs of the Collaborative Pediatric Critical Care Research Network. PATIENTS: Children (< 19 yr old) who received greater than or equal to 1 minute of cardiopulmonary res...
Recent pediatric clinical research has begun to focus on risk stratification tools using multibiomarker models. C-reactive protein (CRP) and ferriti biomarkers are widely available and used to varying degrees in daily practice, but there is no single source examining the evidence behind their use. We set out to summarize the evidence behind the use of CRP and ferritin biomarkers in pediatric practice and to begin development of a consensus for their future use for pediatricians. All the literatu...
#1Hernando Gomez Danies (University of Pittsburgh)H-Index: 1
#2Joseph A. Carcillo (University of Pittsburgh)H-Index: 51
#1Jennifer K. Workman (UofU: University of Utah)H-Index: 3
#2David K. Bailly (UofU: University of Utah)H-Index: 5
Last. Joseph A. Carcillo (Boston Children's Hospital)H-Index: 9
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Risk factors for mortality in children with refractory pediatric septic shock who are supported with extracorporeal life support (ECLS) are largely unknown. Therefore, we performed univariable and multivariable analyses to determine risk factors for mortality among children (<19 years) who underwent an ECLS run between January 2012 and September 2014 at eight tertiary pediatric hospitals, and who had septic shock based on 2005 International Consensus Criteria. Of the 514 children treated with EC...
#1John T. BergerH-Index: 25
#2Aline B. MadduxH-Index: 3
Last. Kathleen L. MeertH-Index: 41
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OBJECTIVES: To characterize contemporary use of inhaled nitric oxide in pediatric acute respiratory failure and to assess relationships between clinical variables and outcomes. We sought to study the relationship of inhaled nitric oxide response to patient characteristics including right ventricular dysfunction and clinician responsiveness to improved oxygenation. We hypothesize that prompt clinician responsiveness to minimize hyperoxia would be associated with improved outcomes. DESIGN: An obse...
#1Ericka L. Fink (Boston Children's Hospital)H-Index: 20
#1Ericka L. Fink (Boston Children's Hospital)H-Index: 5
Last. J. Michael Dean (UofU: University of Utah)H-Index: 47
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Abstract Background Pediatric Intensive Care Unit (PICU) teams provide care for critically ill children with diverse and often complex medical and surgical conditions. Researchers often lack guidance on an approach to select the best outcomes when evaluating this critically ill population. Studies would be enhanced by incorporating multi-stakeholder preferences to better evaluate clinical care. This manuscript outlines the methodology currently being used to develop a PICU Core Outcome Set (COS)...