Match!

DXA: Can It Be Used as a Criterion Reference for Body Fat Measurements in Children?

Published on Feb 1, 2008in Obesity3.969
· DOI :10.1038/oby.2007.81
Roman J. Shypailo19
Estimated H-index: 19
(BCM: Baylor College of Medicine),
Nancy F. Butte50
Estimated H-index: 50
(BCM: Baylor College of Medicine),
Kenneth J. Ellis58
Estimated H-index: 58
(BCM: Baylor College of Medicine)
Abstract
Objective: Dual-energy X-ray absorptiometry (DXA) is often cited as a criterion method for body composition measurements. We have previously shown that a new DXA software version (Hologic Discovery V12.1) will affect whole-body bone mineral results for subjects weighing <40 kg. We wished to reanalyze pediatric whole-body scans in order to assess the impact of the new software on pediatric soft-tissue body composition estimates. Methods and Procedures: We reanalyzed 1,384 pediatric scans (for ages 1.7–17.2 years) using Hologic software V12.1, previously analyzed using V11.2. Regression analysis and ANCOVA were used to compare body fat (total body fat (TBF), percentage fat (%BF)), and non-bone lean body mass (LBM) for the two versions, adjusting for gender, age and weight. Results: Software V12.1 yielded values that were higher for TBF, lower for LBM, and unchanged for DXA-derived weight in subjects weighing <40 kg. Body composition values for younger, smaller subjects were most affected, and girls were more affected than boys. Using the new software, 14% of the girls and 10% of the boys were reclassified from the “normal” %BF range to “at risk of obesity,” while 7 and 5%, respectively, were reclassified as obese. Discussion: Hologic's newest DXA software has a significant effect on soft-tissue results for children weighing <40 kg. The effect is greater for girls than boys. Comparison of TBF estimates with previous studies that use older DXA instruments and software should be done with caution. DXA has not yet achieved sufficient reliability to be considered a “gold standard” for body composition assessment in pediatric studies.
  • References (34)
  • Citations (46)
📖 Papers frequently viewed together
35.1k Citations
20045.40Pediatrics
6 Authors (Aviva B. Sopher, ..., Mary Horlick)
169 Citations
200027.60BMJ
4 Authors (Tim J. Cole, ..., William H. Dietz)
12k Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References34
Newest
#1Kenneth J. Ellis (BCM: Baylor College of Medicine)H-Index: 58
#2Roman J. Shypailo (BCM: Baylor College of Medicine)H-Index: 19
Pencil-beam dual-energy X-ray absorptiometers (DXA) are being replaced with instruments that rely solely on fan-beam technology. However, information has been lacking regarding the translation of bone mineral and body composition data between the two devices. We have compared total body scans using pencil-beam (Hologic QDR-2000W) and fan-beam (Hologic QDR-4500A) instruments for 33 children (ages 3–18 years) and 14 adults. Bone mineral content (BMC), bone mineral density (BMD), fat, lean, and bod...
101 CitationsSource
#1Kenneth E. Thorpe (Emory University)H-Index: 29
Summary Objectives To examine the factors responsible for the rise in health- care spending in the United States over the past 15 years. Study Design and Methods Nationally representative survey data from 1987 and 2003 were used to examine the top medical conditions accounting for the rise in spending. I also estimate how much of the rise is traced to rising treated disease prevalence and rising spending per case. Results The study finds most of the rise in spending is linked to rising rates of ...
66 CitationsSource
#1Cynthia L. Ogden (CDC: Centers for Disease Control and Prevention)H-Index: 59
#2Margaret D. Carroll (CDC: Centers for Disease Control and Prevention)H-Index: 56
Last. Katherine M. Flegal (CDC: Centers for Disease Control and Prevention)H-Index: 88
view all 6 authors...
ContextThe prevalence of overweight in children and adolescents and obesity in adults in the United States has increased over several decades.ObjectiveTo provide current estimates of the prevalence and trends of overweight in children and adolescents and obesity in adults.Design, Setting, and ParticipantsAnalysis of height and weight measurements from 3958 children and adolescents aged 2 to 19 years and 4431 adults aged 20 years or older obtained in 2003-2004 as part of the National Health and N...
7,823 CitationsSource
#1Wei Shen (Columbia University)H-Index: 33
#2Mark Punyanitya (Columbia University)H-Index: 23
Last. Steven B. Heymsfield (Columbia University)H-Index: 123
view all 10 authors...
Objective: Percent fat is often considered the reference for establishing the magnitude of adipose tissue accumulation and the risk of excess adiposity. However, the increasing recognition of a strong link between central adiposity and metabolic disturbances led us to test whether waist circumference (WC) is more highly correlated with metabolic syndrome components than percent fat and other related anthropometric measures such as BMI. Research Methods and Procedures: BMI, WC, and percent fat, m...
163 CitationsSource
#1Roman J. Shypailo (BCM: Baylor College of Medicine)H-Index: 19
#2Kenneth J. Ellis (BCM: Baylor College of Medicine)H-Index: 58
Abstract The newest version of whole body dual-energy X-ray absorptiometry (DXA) analysis software from Hologic (Discovery 12.1) is designed to enhance bone detection in smaller subjects. We re-analyzed 1127 pediatric scans (ages 1.8–18.5 yr) previously analyzed using software version 11.2. Regression analysis compared new and original results for bone area (BA), bone mineral content (BMC), bone mineral density (BMD), and DXA-derived body weight. Changes in total and regional bone results were c...
20 CitationsSource
#1Angelo PietrobelliH-Index: 55
#2Attilio L. BonerH-Index: 48
Last. Luciano TatòH-Index: 38
view all 3 authors...
BACKGROUND: Epidemiologic evidence supports the theory that the relation between obesity and disease risk begins early in life, and those risk factors for disease track, or remain at a similar level, with advancing age, growth, and development. The fat tissue, once considered as a depot for energy substrate, is a metabolically active tissue. The fat cells produce agents that regulate a host of physiological processes directly related to carbohydrate and fat metabolism and the development of card...
46 CitationsSource
#1Manning Feinleib (Johns Hopkins University)H-Index: 43
1,510 CitationsSource
#1Madlyn I. Frisard (Pennington Biomedical Research Center)H-Index: 21
#2Frank L. Greenway (Pennington Biomedical Research Center)H-Index: 56
Last. James P. DeLany (Pennington Biomedical Research Center)H-Index: 43
view all 3 authors...
Objective: To assess the accuracy of body composition measurements by air displacement plethysmography and bioelectrical impedance analysis (BIA) compared with DXA during weight loss. Research Methods and Procedures: Fifty-six healthy but overweight participants, 34 women and 22 men (age, 52 ± 8.6 years; weight, 92.2 ± 11.6 kg; BMI, 33.3 ± 2.9 kg/m2) were studied in an outpatient setting before and after 6 months of weight loss (weight loss, 5.6 ± 5.5 kg). Subjects were excluded if they had init...
107 CitationsSource
#1Julia Steinberger (UMN: University of Minnesota)H-Index: 60
#2David R. Jacobs (UMN: University of Minnesota)H-Index: 148
Last. Alan R. Sinaiko (UMN: University of Minnesota)H-Index: 49
view all 6 authors...
Comparison of body fatness measurements by BMI and skinfolds vs dual energy X-ray absorptiometry and their relation to cardiovascular risk factors in adolescents
156 CitationsSource
#1Joey C. Eisenmann (Iowa State University)H-Index: 52
#2Kate A. Heelan (UNK: University of Nebraska at Kearney)H-Index: 15
Last. Gregory J. Welk (Iowa State University)H-Index: 52
view all 3 authors...
EISENMANN, JOEY C., KATE A. HEELAN, AND GREGORY J. WELK. Assessing body composition among 3- to 8-year-old children: anthropometry, BIA, and DXA. Obes Res. 2004;12:1633–1640. Objective: To examine the inter-relationships of body composition variables derived from simple anthropometry [BMI and skinfolds (SFs)], bioelectrical impedance analysis (BIA), and dual energy x-ray (DXA) in young children. Research Methods and Procedures: Seventy-five children (41 girls, 34 boys) 3 to 8 years of age were a...
180 CitationsSource
Cited By46
Newest
#1Roman J. Shypailo (BCM: Baylor College of Medicine)H-Index: 19
#2William W. Wong (BCM: Baylor College of Medicine)H-Index: 47
BACKGROUND Fat-free mass index (FFMI) and fat mass index (FMI) are superior to BMI and fat percentage in evaluating nutritional status. However, existing references fail to account for racial/ethnic differences in body composition among children. OBJECTIVES Our goal was to produce age-based normative references for FFMI and FMI in children for specific racial/ethnic groups. METHODS Body composition, weight, and height were measured in 1122 normal healthy children aged 2-21 y. Bone mineral conten...
Source
#1Camila E. Orsso (U of A: University of Alberta)H-Index: 3
#2Maria Ines Barreto Silva (UERJ: Rio de Janeiro State University)
Last. Andrea M. Haqq (U of A: University of Alberta)H-Index: 20
view all 7 authors...
Accurate measurement of body composition is required to improve health outcomes in children and adolescents with overweight or obesity. This systematic review aimed to summarize the reliability and validity of field and laboratory body composition techniques employed in pediatric obesity studies to facilitate technique selection for research and clinical practice implementation. A systematic search in MEDLINE (via PubMed), EMBASE, CINAHL, and SPORTDiscus from inception up to December 2019 was co...
Source
#1Kristin GodangH-Index: 28
#2Karolina LundstamH-Index: 2
Last. Ansgar HeckH-Index: 10
view all 11 authors...
Context: Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors. Objective: To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism. Design, patients, interventions, main outcome measures: 119 patients previously randomized to observation (OBS; n = 58) or parathyroidectomy (PTX; n = 61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter...
1 CitationsSource
#1Gert-Jan van der Heijden (BCM: Baylor College of Medicine)H-Index: 2
#2Zhiyue J. Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
Last. Agneta L. Sunehag (BCM: Baylor College of Medicine)H-Index: 24
view all 6 authors...
Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat ≥ 27%; n = 15) and Normal BMI and Normal Fat content (N-BM...
Source
Obesity is defined as an abnormal or excessive fat accumulation that may impair health. Dual-energy X-ray absorptiometry (DEXA) has been suggested as the gold standard to define obesity, but because its use is complex and expensive, anthropometric measures such as body mass index (BMI) or the waist-to-height ratio (WtHr) have been used as alternatives. The aim of this study was to review the published literature and investigate the correlation of BMI and WtHr with body fat (BF) measured by DEXA ...
19 CitationsSource
#1Linda A. Barbour (Anschutz Medical Campus)H-Index: 31
#2Teri L. Hernandez (Anschutz Medical Campus)H-Index: 22
Last. R. E. Van Pelt (Anschutz Medical Campus)H-Index: 8
view all 9 authors...
Summary Background Infant adiposity better predicts childhood obesity/metabolic risk than weight, but technical challenges fuel controversy over the accuracy of adiposity estimates. Objective We prospectively measured adiposity (%fat) in term newborns (NB) at 2 weeks (n = 41) and 1 year (n = 30). Methods %fat was measured by dual X-ray absorptiometry (DXA), PEAPOD and skin-folds (SF). DXAs were analyzed using Hologic Apex software 3.2(DXAv1) and a new version 5.5.2(DXAv2). Results NB %fat by DXA...
7 CitationsSource
#1Fima LifshitzH-Index: 23
#2J P Hecht (UBA: University of Buenos Aires)H-Index: 1
Last. Patricia Rodriguez (UBA: University of Buenos Aires)H-Index: 8
view all 8 authors...
Dual-energy X-ray absorptiometry (DXA) is considered a specific method for measuring body composition to assess obesity and osteoporosis, although few studies have been conducted in preschool children. The aim of this study was to provide sex - and age-specific references for bone mineral density (BMD), bone mineral content (BMC), fat mass (FM) and fat-free mass (FFM) normative data for children aged 2 to <6 years. One hundred and eighty seven healthy white children from Buenos Aires City suburb...
2 CitationsSource
#1Nivedita PatniH-Index: 9
#2Crésio Alves (UFBA: Federal University of Bahia)H-Index: 15
Last. Abhimanyu GargH-Index: 14
view all 7 authors...
Context: A rare presentation of hypothalamic tumors in infants and young children is profound emaciation and generalized loss of sc adipose tissue, also known as “diencephalic syndrome.” Similar loss of sc fat can be observed in children with acquired generalized lipodystrophy or congenital generalized lipodystrophy. Precise diagnosis may be challenging early in the course of the disease, especially in the absence of metabolic abnormalities. Case Description: We report three males who presented ...
9 CitationsSource
#1Mark Simmonds (Ebor: University of York)H-Index: 25
#2Jane Burch (Ebor: University of York)H-Index: 18
Last. Nerys Woolacott (Ebor: University of York)H-Index: 35
view all 8 authors...
BACKGROUND: It is uncertain which simple measures of childhood obesity are best for predicting future obesity-related health problems and the persistence of obesity into adolescence and adulthood. OBJECTIVES: To investigate the ability of simple measures, such as body mass index (BMI), to predict the persistence of obesity from childhood into adulthood and to predict obesity-related adult morbidities. To investigate how accurately simple measures diagnose obesity in children, and how acceptable ...
87 CitationsSource
#1Pilar De Miguel-Etayo (University of Zaragoza)H-Index: 6
#2Luis Alberto Moreno Aznar (University of Zaragoza)H-Index: 80
Last. J. M. Garagorri (University of Zaragoza)H-Index: 14
view all 10 authors...
summary Background & aims: The main objectives of weight loss interventions in children and adolescents are to decrease fat mass while maintaining fat-free mass. Several methods are available to assess childhood and adolescence obesity, such as weight and height, bioelectrical impedance, skin-fold thickness measurements and other laboratory methods. The aim was to assess simple anthropometric indices as predictors of body-fat changes, using dual-energy X-ray absorptiometry measurements as refere...
12 CitationsSource