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Rediscovering the sweet spot in drug discovery

Published on Dec 1, 2003in Drug Discovery Today6.88
· DOI :10.1016/S1359-6446(03)02902-7
David Brown4
Estimated H-index: 4
(University of Hertfordshire),
Giulio Superti-Furga73
Estimated H-index: 73
Abstract
Advances over the past decade in drug discovery technologies have not yet led to an increase in productivity. We analyzed the reasons that have led to this juncture and identify the selection of the right target and the right lead as crucial. New approaches are required to take full advantage of the genomics revolution. For targets, methods are becoming available for high-throughput proteome analysis and pathway characterization that synergize with studies of disease association and differential expression. For leads, methods are being developed that ‘reverse’ the high-throughput screening paradigm by mapping drugs and drug-like compounds back onto the proteome. The synergy between pathway mapping and compound mapping could allow the pharmaceutical and biotechnology industries to rediscover the sweet spot of research productivity.
  • References (44)
  • Citations (143)
References44
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#1Donmienne Leung (Scripps Research Institute)H-Index: 7
#2Christophe Hardouin (Scripps Research Institute)H-Index: 7
Last.Benjamin F. Cravatt (Scripps Research Institute)H-Index: 112
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#1Konrad Bleicher (Hoffmann-La Roche)H-Index: 15
#2Hans-Joachim Böhm (Hoffmann-La Roche)H-Index: 25
Last.Alexander Alanine (Hoffmann-La Roche)H-Index: 16
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Cited By143
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#1Andrea Volkamer (Humboldt University of Berlin)H-Index: 7
#2Mathias M. von Behren (UHH: University of Hamburg)H-Index: 2
Last.Matthias Rarey (UHH: University of Hamburg)H-Index: 34
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#1P. Kumar (JNU: Jawaharlal Nehru University)H-Index: 1
#2R. Kaalia (NTU: Nanyang Technological University)H-Index: 1
Last.Indira Ghosh (JNU: Jawaharlal Nehru University)H-Index: 13
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#1Manuel Llano (UTEP: University of Texas at El Paso)H-Index: 7
#2Mario A. Peña-Hernandez (UTEP: University of Texas at El Paso)H-Index: 1
#1Naiem T. Issa (GUMC: Georgetown University Medical Center)H-Index: 6
#2Stephen W. Byers (Georgetown University)H-Index: 43
Last.Sivanesan Dakshanamurthy (Georgetown University)H-Index: 23
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View next paperThe druggable genome