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Relapse in Major Depressive Disorder: Analysis With the Life Table

Published on Aug 1, 1982in Archives of General Psychiatry
· DOI :10.1001/archpsyc.1982.04290080031005
Martin B. Keller116
Estimated H-index: 116
,
Robert W. Shapiro14
Estimated H-index: 14
+ 1 AuthorsNicola Wolfe2
Estimated H-index: 2
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Abstract
• With the use of life tables to describe time while patients were well and subsequent rates of relapse for 75 patients after their recovery from an episode of major depressive disorder in a naturalistic study, a high risk of relapse was detected shortly after recovery. Twenty-four percent of patients relapsed within 12 weeks at risk, and 12% of patients relapsed within four weeks at risk. The presence of an underlying chronic depression and three or more previous affective episodes predicted a statistically significant increase in the rate of relapse. These data were used to develop an exponential model of relapse probability for a subgroup of the study population.
  • References (21)
  • Citations (216)
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References21
Newest
Published on Apr 1, 1982in American Journal of Psychiatry 13.65
Martin B. Keller116
Estimated H-index: 116
,
Robert W. Shapiro14
Estimated H-index: 14
Although ‘ ‘double depression ‘ ‘-major depressive disorder superimposed on an underlying chronic depression-is a f requent phenomenon, the concept has not been well formulated clinically and has rarely been described in the research literature. The authors found that 1) 26% of 101 patients who met the criteria for major depressive disorder had an underlying chronic depressive disorder of at least 2 years’ duration, 2) “recovery” ratesfor patients with superimposed depression differed greatly de...
284 Citations Source Cite
Published on Dec 1, 1981in Journal of Nervous and Mental Disease 1.86
Martin B. Keller116
Estimated H-index: 116
,
Robert W. Shapiro14
Estimated H-index: 14
The authors present a 1-year prospective, naturalistic, longitudinal follow-up of 101 patients with the Research Diagnostic Criteria diagnosis of definite major depressive disorder. Seventy-four per cent of patients recover by 1 year. Of those who do recover, 36. per cent have subsequent Research Diagnostic Criteria affective episodes within the year. Episodes are of long duration for both the recovered and nonrecovered patients, being 30 weeks and at least 99 weeks, respectively. Certain common...
98 Citations Source Cite
Published on Sep 1, 1981in Journal of Affective Disorders 4.08
Robert W. Shapiro14
Estimated H-index: 14
(Massachusetts Mental Health Center),
Martin B. Keller116
Estimated H-index: 116
(Harvard University)
Abstract Results from 121 patients with major depressive disorder followed-up at 6 months with a new comprehensive follow-up schedule, the Longitudinal Interval Follow-Up Evaluation (LIFE) indicate that: 1. (1) Forty percent of patients had not recovered from the index episode 6 months after inclusion; 2. (2) Of those patients who recovered, 19% relapsed into another RDC affective episode by the time of the 6-months follow-up, and an additional 24% developed some subsequent affective symptoms by...
50 Citations Source Cite
Published on Jan 1, 1981in Archives of General Psychiatry
Jean Endicott93
Estimated H-index: 93
,
Jacob Cohen65
Estimated H-index: 65
+ 2 AuthorsStavros Sarantakos6
Estimated H-index: 6
• Investigators who wish to use new procedures usually wish to relate their results to those already in the literature. This often results in the use of both old and new measures. The Schedule for Affective Disorders and Schizophrenia Regular and Change Versions (SADS and SADS-C) have advantages over the widely used Hamilton Depression Rating Scale (HDRS). A procedure was developed to extract the HDRS score from the SADS and SADS-C. The comparative reliability and the validity of the extracted H...
340 Citations Source Cite
Published on Jul 20, 1979in Archives of General Psychiatry
Athanasios P. Zis36
Estimated H-index: 36
,
Frederick K. Goodwin87
Estimated H-index: 87
The systematic study of the natural course of affective disorders originated with the pioneer work of Kraepelin 1 and has continued until recently. However, with the advent of lithium and its widespread use in the prophylaxis of affective disorders, naturalistic data on the course of the illness has become increasingly unavailable. While reviewing the literature on the subject, one is struck by the discrepancies in the reported results and particularly the disparities concerning the proportion o...
162 Citations Source Cite
Published on Jul 1, 1979in Archives of General Psychiatry
Martin M. Katz20
Estimated H-index: 20
(NIH: National Institutes of Health),
Steven Secunda5
Estimated H-index: 5
(NIH: National Institutes of Health)
+ 1 AuthorsStephen H. Koslow34
Estimated H-index: 34
(NIH: National Institutes of Health)
• This is a report on the history and implications of the collaborative effort that evolved from the 1969 National Institute of Mental Health conference on the psychobiology of depression. The major issues identified at that time were the need to (1) assess relative validities of current systems of nosology and (2) retest critical biological hypotheses concerning the etiology and nature of the depressive disorders. Research was required that would be multidisciplinary and involve clinical settin...
192 Citations Source Cite
Published on Jul 1, 1978in Comprehensive Psychiatry 2.59
Joseph L. Fleiss66
Estimated H-index: 66
,
Robert F. Prien5
Estimated H-index: 5
+ 1 AuthorsRonald R. Fieve43
Estimated H-index: 43
Abstract The existence of two large-scale comparative longitudinal studies of lithium prophylaxis 1,2 provides a rare opportunity for comparing and combining information on the course of manic-depressive illness and how the course is modified when patients are maintained on lithium carbonate. This report describes our success in constructing relatively simple mathematic models for the rates of relapse in manic-depressive illness under both lithium carbonate and control treatment using data from ...
15 Citations Source Cite
Published on Jun 1, 1978in Archives of General Psychiatry
Robert L. Spitzer85
Estimated H-index: 85
,
Jean Endicott93
Estimated H-index: 93
,
Eli Robins48
Estimated H-index: 48
• A crucial problem in psychiatry, affecting clinical work as well as research, is the generally low reliability of current psychiatric diagnostic procedures. This article describes the development and initial reliability studies of a set of specific diagnostic criteria for a selected group of functional psychiatric disorders, the Research Diagnostic Criteria (RDC). The RDC are being widely used to study a variety of research issues, particularly those related to genetics, psychobiology of selec...
5,539 Citations Source Cite
Published on Jan 1, 1978in Comprehensive Psychiatry 2.59
Myrna M. Weissman6
Estimated H-index: 6
(Yale University),
Brigitte A. Prusoff1
Estimated H-index: 1
(Yale University),
Gerald L. Klerman75
Estimated H-index: 75
(Yale University)
Abstract Anyclinician who follows patients under naturalistic clinic conditions accumulates a wealth of observations about their responses to various treatments. Without random assignment to treatment or other features of the controlled experimental design, information on treatment efficacy obtained from these naturally occurring situations is limited. However, through the use of appropriate statistical techniques such as life table method, considerably more information may be extracted. Althoug...
6 Citations Source Cite
Published on Jan 1, 1977
Myrna M. Wiessman1
Estimated H-index: 1
(Yale University)
I would like to discuss this subject by drawing from my own experiences, which may present a familiar topic from a different vantage point. I’l1 describe research on the outpatient treatment of primary depression, in which I’ve collaborated since 1967 with Drs. Gerald Klerman and Alberto DiMascio, and Ms. Brigitte Prusoff. This research is relevant to the topic since it included a twenty-month study with both controlled and naturalistic phases. I will also draw upon my training in epidemiology, ...
7 Citations Source Cite
Cited By216
Newest
Published on Oct 30, 2018in Clinical Infectious Diseases 9.05
Jon C. Mills3
Estimated H-index: 3
(UNC: University of North Carolina at Chapel Hill),
Brian W. Pence34
Estimated H-index: 34
(UNC: University of North Carolina at Chapel Hill)
+ 15 AuthorsSeble Kassaye11
Estimated H-index: 11
(Georgetown University)
6 Citations Source Cite
Published on Dec 6, 2017in Substance Use & Misuse 1.38
Ye Zhang Pogue1
Estimated H-index: 1
(Brandeis University),
Jahn K. Hakes15
Estimated H-index: 15
(United States Census Bureau),
Frank A. Sloan63
Estimated H-index: 63
(Duke University)
ABSTRACTBackground: Alcohol-impaired driving causes a substantial proportion of motor vehicle accidents. Depression is a prevalent psychiatric disorder among drinker-drivers. Few previous studies have investigated the relationship between major depression and alcohol-impaired driving. Objectives: We investigated whether depression has a positive relationship with the probability of alcohol-impaired driving after controlling for the co-occurrence of binge drinking and alcohol dependence. Methods:...
1 Citations Source Cite
Published on Sep 1, 2017in Social Psychiatry and Psychiatric Epidemiology 3.15
Stephanie Rodgers14
Estimated H-index: 14
(UZH: University of Zurich),
Caroline L. Vandeleur17
Estimated H-index: 17
(UNIL: University of Lausanne)
+ 8 AuthorsVladeta Ajdacic-Gross28
Estimated H-index: 28
(UZH: University of Zurich)
Purpose Given the broad range of biopsychosocial difficulties resulting from major depressive disorder (MDD), reliable evidence for predictors of improved mental health is essential, particularly from unbiased prospective community samples. Consequently, a broad spectrum of potential clinical and non-clinical predictors of improved mental health, defined as an absence of current major depressive episode (MDE) at follow-up, were examined over a 5-year period in an adult community sample.
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Published on Jan 1, 2017in Journal of Affective Disorders 4.08
Waguih William IsHak20
Estimated H-index: 20
(UCLA: University of California, Los Angeles),
Wes Bonifay5
Estimated H-index: 5
(MU: University of Missouri)
+ 5 AuthorsLi Cai23
Estimated H-index: 23
(UCLA: University of California, Los Angeles)
Abstract Background Clinicians view “recovery” as the reduction in severity of symptoms over time, whereas patients view it as the restoration of premorbid functioning level and quality of life (QOL). The main purpose of this study is to incorporate patient-reported measures of functioning and QOL into the assessment of patient outcomes in MDD and to use this data to define recovery. Method Using the STAR*D study of patients diagnosed with MDD, this present analysis grades patients' MDD severity...
2 Citations Source Cite
Published on Jan 1, 2017
Neal L. Cohen1
Estimated H-index: 1
2 Citations
Published on Jan 1, 2017in Acta Psychiatrica Scandinavica 4.69
Lars Vedel Kessing50
Estimated H-index: 50
(UCPH: University of Copenhagen),
Per Kragh Andersen73
Estimated H-index: 73
(UCPH: University of Copenhagen)
Objective It is a widely held belief that affective disorders are progressive of nature; however, some recent reviews have questioned this belief. The objective of the present systematic literature review was to present evidence for associations between number of affective episodes and (i) the risk of recurrence of episodes, (ii) probability of recovery from episodes, (iii) severity of episodes, (iv) the threshold for developing episodes, and (v) progression of cognitive deficits in unipolar and...
31 Citations Source Cite
Published on Dec 1, 2016in Journal of Psychopharmacology 4.22
James Rucker11
Estimated H-index: 11
('KCL': King's College London),
Luke A. Jelen2
Estimated H-index: 2
('KCL': King's College London)
+ 2 AuthorsAllan H. Young69
Estimated H-index: 69
('KCL': King's College London)
Unipolar mood disorders, including major depressive disorder and persistent depressive disorder (dysthymia), confer high rates of disability and mortality and a very high socioeconomic burden. Current treatment is suboptimal in most cases and there is little of note in the pharmaceutical development pipeline. The psychedelic drugs, including lysergic acid diethylamide and psilocybin, were used extensively in the treatment of mood disorders, and other psychiatric conditions, before their prohibit...
16 Citations Source Cite
Published on Aug 13, 2016 in KDD (Knowledge Discovery and Data Mining)
Zhi Nie1
Estimated H-index: 1
(ASU: Arizona State University),
Pinghua Gong12
Estimated H-index: 12
(UM: University of Michigan),
Jieping Ye18
Estimated H-index: 18
(UM: University of Michigan)
Depression is a serious mood disorder afflicting millions of people around the globe. Medications of different types and with different effects on neural activity have been developed for its treatments during the past few decades. Due to the heterogeneity of the disorder, many patients cannot achieve symptomatic remission from a single clinical trial. Instead they need multiple clinical trials to achieve remission, resulting in a multiple stage treatment pattern. Furthermore those who indeed ach...
1 Citations Source Cite
Published on Apr 30, 2016in Journal of Neurogastroenterology and Motility 3.18
Pontus Karling16
Estimated H-index: 16
(Umeå University),
Mikael Wikgren6
Estimated H-index: 6
(Umeå University)
+ 1 AuthorsKarl-Fredrik Norrback20
Estimated H-index: 20
(Umeå University)
Background/Aims: Gastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to i ...
2 Citations Source Cite
Published on Jan 1, 2016in Biological & Pharmaceutical Bulletin 1.54
Kazuyuki Inoue22
Estimated H-index: 22
(University of Shizuoka),
Takuma Murofushi (University of Shizuoka)+ 8 AuthorsDaiki Tsuji9
Estimated H-index: 9
(University of Shizuoka)
To prevent recurrent depression, patients should ideally continue treatment for >6 months with the antidepressant dose that effectively suppressed acute depressive symptoms. However, there are inter-individual differences in the antidepressant doses required to achieve response and maintenance. Therefore, this study was conducted to examine the role of clinical features, including genetic polymorphisms, on the antidepressant dose required for maintenance therapy in 82 Japanese patients with depr...
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