O3-02-05: Potential role of orexin in the pathogenesis of Alzheimer's disease

Age-related aggregation of beta-amyloid is an upstream pathologic event before the clinical onset of Alzheimer's disease (AD). Aggregation of beta-amyloid disrupts the sleep-wake cycle and normal physiological fluctuation of beta-amyloid in the brain. The amount of sleep declines with aging and to a greater extent in AD and recent study showed that the sleep quality is abnormal during the phase of preclinical AD in humans. However, how the...